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The Journal of Neuroscience, September 1, 2002, 22(17):7766-7773

Activation of a Cortical Column by a Thalamocortical Impulse

Harvey A. Swadlow¹, Alexander G. Gusev^{1, 2}, and Tatiana Bezdudnaya^{1, 3}

¹ Department of Psychology, The University of Connecticut, Storrs, Connecticut 06269, ² Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Medical Sciences, Moscow 117865, Russia, and ³ A. B. Kogan Research Institute for Neurocybernetics, Rostov-on-Don 344090, Russia

Thalamocortical (TC) impulses potently influence the sensory neocortex, but the functional impact of individual TC neurons throughout the layers of the cortex has proved difficult to assess. Here we examine, in awake rabbits, the vertical distribution of monosynaptic currents generated in a somatosensory cortical "barrel" column by spontaneous impulses of single, topographically aligned TC neurons. We show that closely neighboring TC neurons generate widely differing patterns of monosynaptic activation within layers 4 and 6 of their aligned column. Moreover, synaptic currents generated by TC impulses with long preceding interspike intervals are greatly enhanced in both of these layers. The degree of this enhancement differs reliably among neighboring TC neurons but, for a given neuron, is very similar in layers 4 and 6. Our results indicate that in the awake state, TC synapses throughout the depth of the cortex serve as powerful filters of sensory information that reflect individual characteristics of their parent TC neuron.

Key words: thalamocortical synapse; somatosensory cortex; cortical column; barrel; current source-density analysis; synaptic depression

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Copyright © 2002 Society for Neuroscience  0270-6474/02/22177766-08$05.00/0

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