QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (33) Citing Articles via Google Scholar Google Scholar Articles by Ramanathan, S. Articles by Bolam, J. P. Search for Related Content PubMed PubMed Citation Articles by Ramanathan, S. Articles by Bolam, J. P.

 Previous Article  |  Next Article 

The Journal of Neuroscience, September 15, 2002, 22(18):8158-8169

Synaptic Convergence of Motor and Somatosensory Cortical Afferents onto GABAergic Interneurons in the Rat Striatum

Sankari Ramanathan¹, Jason J. Hanley¹, Jean-Michel Deniau², and J. Paul Bolam¹

¹ Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford, OX1 3TH, United Kingdom, and ² Institut National de la Santé et de la Recherche Médicale U114, Collège de France, 75321 Paris Cedex 05, France

Cortical afferents to the basal ganglia, and in particular the corticostriatal projections, are critical in the expression of basal ganglia function in health and disease. The corticostriatal projections are topographically organized but also partially overlap and interdigitate. To determine whether projections from distinct cortical areas converge at the level of single interneurons in the striatum, double anterograde labeling from the primary motor (M1) and primary somatosensory (S1) cortices in the rat, was combined with immunolabeling for parvalbumin (PV), to identify one population of striatal GABAergic interneurons.

Cortical afferents from M1 and S1 gave rise to distinct, but partially overlapping, arbors of varicose axons in the striatum. PV-positive neurons were often apposed by cortical terminals and, in many instances, apposed by terminals from both cortical areas. Frequently, individual cortical axons formed multiple varicosities apposed to the same PV-positive neuron. Electron microscopy confirmed that the cortical terminals formed asymmetric synapses with the dendrites and perikarya of PV-positive neurons as well as unlabelled dendritic spines. Correlated light and electron microscopy revealed that individual PV-positive neurons received synaptic input from axon terminals derived from both motor and somatosensory cortices.

These results demonstrate that, within areas of overlap of functionally distinct projections, there is synaptic convergence at the single cell level. Sensorimotor integration in the basal ganglia is thus likely to be mediated, at least in part, by striatal GABAergic interneurons. Furthermore, our findings suggest that the pattern of innervation of GABAergic interneurons by cortical afferents is different from the cortical innervation of spiny projection neurons.

Key words: GABA; striatum; corticostriatal; parvalbumin; cortex; basal ganglia

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/22188158-12$05.00/0

This article has been cited by other articles:

				M. G. Cunningham, S. Bhattacharyya, and F. M. Benes Increasing Interaction of Amygdalar Afferents with GABAergic Interneurons between Birth and Adulthood Cereb Cortex, July 1, 2008; 18(7): 1529 - 1535. [Abstract] [Full Text] [PDF]

				E. Fino, J.-M. Deniau, and L. Venance Cell-specific spike-timing-dependent plasticity in GABAergic and cholinergic interneurons in corticostriatal rat brain slices J. Physiol., January 1, 2008; 586(1): 265 - 282. [Abstract] [Full Text] [PDF]

				A. R. Sadek, P. J. Magill, and J. P. Bolam A Single-Cell Analysis of Intrinsic Connectivity in the Rat Globus Pallidus J. Neurosci., June 13, 2007; 27(24): 6352 - 6362. [Abstract] [Full Text] [PDF]

				M. Uchigashima, M. Narushima, M. Fukaya, I. Katona, M. Kano, and M. Watanabe Subcellular Arrangement of Molecules for 2-Arachidonoyl-Glycerol-Mediated Retrograde Signaling and Its Physiological Contribution to Synaptic Modulation in the Striatum J. Neurosci., April 4, 2007; 27(14): 3663 - 3676. [Abstract] [Full Text] [PDF]

				S. N. Haber, K.-S. Kim, P. Mailly, and R. Calzavara Reward-Related Cortical Inputs Define a Large Striatal Region in Primates That Interface with Associative Cortical Connections, Providing a Substrate for Incentive-Based Learning. J. Neurosci., August 9, 2006; 26(32): 8368 - 8376. [Abstract] [Full Text] [PDF]

				N. Mallet, B. Ballion, C. Le Moine, and F. Gonon Cortical inputs and GABA interneurons imbalance projection neurons in the striatum of parkinsonian rats. J. Neurosci., April 5, 2006; 26(14): 3875 - 3884. [Abstract] [Full Text] [PDF]

				N. Mallet, C. Le Moine, S. Charpier, and F. Gonon Feedforward Inhibition of Projection Neurons by Fast-Spiking GABA Interneurons in the Rat Striatum In Vivo J. Neurosci., April 13, 2005; 25(15): 3857 - 3869. [Abstract] [Full Text] [PDF]

				E. Bracci, D. Centonze, G. Bernardi, and P. Calabresi Engagement of Rat Striatal Neurons by Cortical Epileptiform Activity Investigated With Paired Recordings J Neurophysiol, November 1, 2004; 92(5): 2725 - 2737. [Abstract] [Full Text] [PDF]

				S. J. Slaght, T. Paz, M. Chavez, J.-M. Deniau, S. Mahon, and S. Charpier On the Activity of the Corticostriatal Networks during Spike-and-Wave Discharges in a Genetic Model of Absence Epilepsy J. Neurosci., July 28, 2004; 24(30): 6816 - 6825. [Abstract] [Full Text] [PDF]

				L. M. Billings and J. F. Marshall Glutamic Acid Decarboxylase 67 mRNA Regulation in Two Globus Pallidus Neuron Populations by Dopamine and the Subthalamic Nucleus J. Neurosci., March 24, 2004; 24(12): 3094 - 3103. [Abstract] [Full Text] [PDF]

				K. T. Blackwell, U. Czubayko, and D. Plenz Quantitative Estimate of Synaptic Inputs to Striatal Neurons during Up and Down States In Vitro J. Neurosci., October 8, 2003; 23(27): 9123 - 9132. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help