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The Journal of Neuroscience, October 1, 2002, 22(19):8466-8475
Constitutive Nuclear Factor- B Activity Is Required for Central
Neuron Survival
Asha L.
Bhakar1,
Laura-Lee
Tannis1,
Christine
Zeindler1,
Maria
Pia
Russo2,
Christian
Jobin2,
David S.
Park3,
Sandra
MacPherson1, and
Philip A.
Barker1
1 Centre for Neuronal Survival, Montreal Neurological
Institute, McGill University, Montreal, Quebec, Canada H3A 2B4,
2 Department of Medicine, University of North Carolina,
Chapel Hill, North Carolina 27599, and 3 Neuroscience
Research Institute, University of Ottawa, Ottawa, Ontario, Canada K1H
8M5
The function of nuclear factor (NF)- B within the developing and
mature CNS is controversial. We have generated transgenic mice to
reveal NF-B transcriptional activity in vivo. As
expected, constitutive NF-B activity was observed within immune
organs, and tumor necrosis factor-inducible NF-B activity was
present in mesenchymal cells. Intriguingly, NF-B activity was also
prominent in the CNS throughout development, especially within
neocortex, olfactory bulbs, amygdala, and hippocampus. NF-B in the
CNS was restricted to neurons and blocked by overexpression of
dominant-negative NF-B-inducible kinase or the IB M super
repressor. Blocking endogenous neuronal NF-B activity in cortical
neurons using recombinant adenovirus induced neuronal death, whereas
induction of NF-B activity increased levels of anti-apoptotic
proteins and was strongly neuroprotective. Together, these data
demonstrate a physiological role for NF-B in maintaining survival of
central neurons.
Key words:
transgenic mouse; adenovirus; NF-B; NIK; RelA; TRAF; apoptosis
Copyright © 2002 Society for Neuroscience 0270-6474/02/22198466-10$05.00/0
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|
|
|
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|
|
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