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The Journal of Neuroscience, October 1, 2002, 22(19):8586-8596

A Novel Mechanism of Dendritic Spine Plasticity Involving Estradiol Induction of Prostaglandin-E₂

Stuart K. Amateau¹ and Margaret M. McCarthy^{1, 2}

¹ Program in Neuroscience and ² Department of Physiology, University of Maryland at Baltimore, School of Medicine, Baltimore, Maryland 21201

The mechanisms establishing and maintaining dendritic spines in the mammalian CNS remain primarily unknown. We report a novel mechanism of neuronal spine plasticity in the developing preoptic area in which estradiol induces prostaglandin-E₂ (PGE₂) synthesis that in turn increases the density of spine-like processes. Estradiol requires PGE₂ synthesis, in vivo and in vitro, and upregulates the dendritic spine protein spinophilin, an effect attenuated by antagonism of the AMPA-kainate receptor. This signaling pathway may involve cross talk between neighboring neurons and astrocytes and appears specific to the preoptic area in that hippocampal neurons responded with an increase in spinophilin to estradiol but not PGE₂. Regionally specific mechanisms of estradiol-mediated synaptic plasticity allow for epigenetic control of complex sex-typic behaviors.

Key words: estrogen; prostaglandin-E₂; dendritic spines; preoptic area; astrocytes; cyclooxygenase-2

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Copyright © 2002 Society for Neuroscience  0270-6474/02/22198586-11$05.00/0

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