 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, October 1, 2002, 22(19):8691-8704
Model of Thalamocortical Slow-Wave Sleep Oscillations and Transitions to Activated States
Maxim Bazhenov1, Igor Timofeev2, Mircea Steriade2, and Terrence J. Sejnowski1, 3 1 The Salk Institute, Howard Hughes Medical Institute, Computational Neurobiology Laboratory, La Jolla, California 92037, 2 Laboratory of Neurophysiology, School of Medicine, Laval University, Quebec, Canada G1K 7P4, and 3 Department of Biology, University of California San Diego, La Jolla, California 92093
During natural slow-wave sleep (SWS) in nonanesthetized cats, silent (down) states alternate with active (up) states; the down states are absent during rapid-eye-movement sleep and waking. Oscillations (<1 Hz) in SWS and transformation to an activated awake state were investigated with intracellular recordings in vivo and with computational models of the corticothalamic system. Occasional summation of the miniature EPSPs during the hyperpolarized (silent) phase of SWS oscillation activated the persistent sodium current and depolarized the membrane of cortical pyramidal (PY) cells sufficiently for spike generation. In the model, this triggered the active phase, which was maintained by lateral PY-PY excitation and persistent sodium current. Progressive depression of the excitatory interconnections and activation of Ca2+-dependent K+ current led to termination of the 20-25 Hz activity after 500-1000 msec. Including thalamocortical (TC) and thalamic reticular neurons in the model increased the duration of the active epochs up to 1-1.5 sec and introduced waning spindle sequences. An increase in acetylcholine activity, which is associated with activated states, was modeled by the reduction in the K+ leak current in PY and TC cells and by a decrease in intracortical PY-PY synaptic conductances. These changes eliminated the hyperpolarizing phases of network activity and transformed cortical neurons to tonic firing at 15-20 Hz. During the transition from SWS to the activated state, the input resistance of cortical neurons gradually increased and, in a fully activated state, reached the same or even higher values as during silent phases of SWS oscillations. The model describes many essential features of SWS and activated states in the thalamocortical system as well as the transition between them.
Key words: slow-wave sleep; waking; thalamus; cortex; sensory input; input resistance; network model
Copyright © 2002 Society for Neuroscience 0270-6474/02/22198691-14$05.00/0
This article has been cited by other articles:
S. K. Esser, S. Hill, and G. Tononi
Breakdown of Effective Connectivity During Slow Wave Sleep: Investigating the Mechanism Underlying a Cortical Gate Using Large-Scale Modeling
J Neurophysiol, October 1, 2009; 102(4): 2096 - 2111.
[Abstract] [Full Text] [PDF]
P. Golshani, J. T. Goncalves, S. Khoshkhoo, R. Mostany, S. Smirnakis, and C. Portera-Cailliau
Internally Mediated Developmental Desynchronization of Neocortical Network Activity
J. Neurosci., September 2, 2009; 29(35): 10890 - 10899.
[Abstract] [Full Text] [PDF]
C. Curto, S. Sakata, S. Marguet, V. Itskov, and K. D. Harris
A Simple Model of Cortical Dynamics Explains Variability and State Dependence of Sensory Responses in Urethane-Anesthetized Auditory Cortex
J. Neurosci., August 26, 2009; 29(34): 10600 - 10612.
[Abstract] [Full Text] [PDF]
S. S. Cash, E. Halgren, N. Dehghani, A. O. Rossetti, T. Thesen, C. Wang, O. Devinsky, R. Kuzniecky, W. Doyle, J. R. Madsen, et al.
The Human K-Complex Represents an Isolated Cortical Down-State
Science, May 22, 2009; 324(5930): 1084 - 1087.
[Abstract] [Full Text] [PDF]
L. Gao, X. Meng, C. Ye, H. Zhang, C. Liu, Y. Dan, M.-m. Poo, J. He, and X. Zhang
Entrainment of Slow Oscillations of Auditory Thalamic Neurons by Repetitive Sound Stimuli
J. Neurosci., May 6, 2009; 29(18): 6013 - 6021.
[Abstract] [Full Text] [PDF]
C.-y. T. Li, M.-m. Poo, and Y. Dan
Burst Spiking of a Single Cortical Neuron Modifies Global Brain State
Science, May 1, 2009; 324(5927): 643 - 646.
[Abstract] [Full Text] [PDF]
D. J. Englot, A. M. Mishra, P. K. Mansuripur, P. Herman, F. Hyder, and H. Blumenfeld
Remote Effects of Focal Hippocampal Seizures on the Rat Neocortex
J. Neurosci., September 3, 2008; 28(36): 9066 - 9081.
[Abstract] [Full Text] [PDF]
A. Fontanini and D. B. Katz
Behavioral States, Network States, and Sensory Response Variability
J Neurophysiol, September 1, 2008; 100(3): 1160 - 1168.
[Abstract] [Full Text] [PDF]
M. V. Sanchez-Vives, V. F. Descalzo, R. Reig, N. A. Figueroa, A. Compte, and R. Gallego
Rhythmic Spontaneous Activity in the Piriform Cortex
Cereb Cortex, May 1, 2008; 18(5): 1179 - 1192.
[Abstract] [Full Text] [PDF]
F. Frohlich, M. Bazhenov, and T. J. Sejnowski
Pathological Effect of Homeostatic Synaptic Scaling on Network Dynamics in Diseases of the Cortex
J. Neurosci., February 13, 2008; 28(7): 1709 - 1720.
[Abstract] [Full Text] [PDF]
H. Okamoto, Y. Isomura, M. Takada, and T. Fukai
Temporal Integration by Stochastic Recurrent Network Dynamics With Bimodal Neurons
J Neurophysiol, June 1, 2007; 97(6): 3859 - 3867.
[Abstract] [Full Text] [PDF]
H. A. Johnson and D. V. Buonomano
Development and Plasticity of Spontaneous Activity and Up States in Cortical Organotypic Slices
J. Neurosci., May 30, 2007; 27(22): 5915 - 5925.
[Abstract] [Full Text] [PDF]
M. Massimini, F. Ferrarelli, S. K. Esser, B. A. Riedner, R. Huber, M. Murphy, M. J. Peterson, and G. Tononi
Triggering sleep slow waves by transcranial magnetic stimulation
PNAS, May 15, 2007; 104(20): 8496 - 8501.
[Abstract] [Full Text] [PDF]
S Lippe, M-S Roy, C Perchet, and M Lassonde
Electrophysiological Markers of Visuocortical Development
Cereb Cortex, January 1, 2007; 17(1): 100 - 107.
[Abstract] [Full Text] [PDF]
W. van Drongelen, H. Koch, F. P. Elsen, H. C. Lee, A. Mrejeru, E. Doren, C. J. Marcuccilli, M. Hereld, R. L. Stevens, and J.-M. Ramirez
Role of Persistent Sodium Current in Bursting Activity of Mouse Neocortical Networks In Vitro
J Neurophysiol, November 1, 2006; 96(5): 2564 - 2577.
[Abstract] [Full Text] [PDF]
A. V. M. Herz, T. Gollisch, C. K. Machens, and D. Jaeger
Modeling single-neuron dynamics and computations: a balance of detail and abstraction.
Science, October 6, 2006; 314(5796): 80 - 85.
[Abstract] [Full Text] [PDF]
F. Frohlich, M. Bazhenov, I. Timofeev, M. Steriade, and T. J. Sejnowski
Slow state transitions of sustained neural oscillations by activity-dependent modulation of intrinsic excitability.
J. Neurosci., June 7, 2006; 26(23): 6153 - 6162.
[Abstract] [Full Text] [PDF]
M. Volgushev, S. Chauvette, M. Mukovski, and I. Timofeev
Precise Long-Range Synchronization of Activity and Silence in Neocortical Neurons during Slow-Wave Sleep
J. Neurosci., May 24, 2006; 26(21): 5665 - 5672.
[Abstract] [Full Text] [PDF]
M. Massimini, F. Ferrarelli, R. Huber, S. K. Esser, H. Singh, and G. Tononi
Breakdown of Cortical Effective Connectivity During Sleep
Science, September 30, 2005; 309(5744): 2228 - 2232.
[Abstract] [Full Text] [PDF]
R. D. Traub, D. Contreras, M. O. Cunningham, H. Murray, F. E. N. LeBeau, A. Roopun, A. Bibbig, W. B. Wilent, M. J. Higley, and M. A. Whittington
Single-Column Thalamocortical Network Model Exhibiting Gamma Oscillations, Sleep Spindles, and Epileptogenic Bursts
J Neurophysiol, April 1, 2005; 93(4): 2194 - 2232.
[Abstract] [Full Text] [PDF]
S. Hill and G. Tononi
Modeling Sleep and Wakefulness in the Thalamocortical System
J Neurophysiol, March 1, 2005; 93(3): 1671 - 1698.
[Abstract] [Full Text] [PDF]
L. Marshall, M. Molle, M. Hallschmid, and J. Born
Transcranial Direct Current Stimulation during Sleep Improves Declarative Memory
J. Neurosci., November 3, 2004; 24(44): 9985 - 9992.
[Abstract] [Full Text] [PDF]
S. Gais and J. Born
Declarative memory consolidation: Mechanisms acting during human sleep
Learn. Mem., November 1, 2004; 11(6): 679 - 685.
[Abstract] [Full Text] [PDF]
M. Molle, L. Marshall, S. Gais, and J. Born
Learning increases human electroencephalographic coherence during subsequent slow sleep oscillations
PNAS, September 21, 2004; 101(38): 13963 - 13968.
[Abstract] [Full Text] [PDF]
M. Massimini, R. Huber, F. Ferrarelli, S. Hill, and G. Tononi
The Sleep Slow Oscillation as a Traveling Wave
J. Neurosci., August 4, 2004; 24(31): 6862 - 6870.
[Abstract] [Full Text] [PDF]
M. Bazhenov, I. Timofeev, M. Steriade, and T. J. Sejnowski
Potassium Model for Slow (2-3 Hz) In Vivo Neocortical Paroxysmal Oscillations
J Neurophysiol, August 1, 2004; 92(2): 1116 - 1132.
[Abstract] [Full Text] [PDF]
E. M. Izhikevich, J. A. Gally, and G. M. Edelman
Spike-timing Dynamics of Neuronal Groups
Cereb Cortex, August 1, 2004; 14(8): 933 - 944.
[Abstract] [Full Text] [PDF]
I. S. Hairston, C. Peyron, D. P. Denning, N. F. Ruby, J. Flores, R. M. Sapolsky, H. C. Heller, and B. F. O'Hara
Sleep Deprivation Effects on Growth Factor Expression in Neonatal Rats: A Potential Role for BDNF in the Mediation of Delta Power
J Neurophysiol, April 1, 2004; 91(4): 1586 - 1595.
[Abstract] [Full Text] [PDF]
A. Fontanini, P. Spano, and J. M. Bower
Ketamine-Xylazine-Induced Slow (< 1.5 Hz) Oscillations in the Rat Piriform (Olfactory) Cortex Are Functionally Correlated with Respiration
J. Neurosci., September 3, 2003; 23(22): 7993 - 8001.
[Abstract] [Full Text] [PDF]
A. Compte, M. V. Sanchez-Vives, D. A. McCormick, and X.-J. Wang
Cellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model
J Neurophysiol, May 1, 2003; 89(5): 2707 - 2725.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|