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The Journal of Neuroscience, October 15, 2002, 22(20):8911-8921
Dopamine Induces a PI3-Kinase-Independent Activation of Akt in Striatal Neurons: A New Route to cAMP Response Element-Binding Protein Phosphorylation
Karen Brami-Cherrier1, Emmanuel Valjent1, Marta Garcia1, Christiane Pagès1, Robert A. Hipskind2, and Jocelyne Caboche1 1 Laboratoire de Neurobiologie des Processus Adaptatifs, Centre National de la Recherche Scientifique/Université Pierre et Marie Curie, Unité Mixte de Recherche 7102, 75005 Paris, France, and 2 Institut de Génétique Moléculaire, Unité Mixte de Recherche 5535, Centre National de la Recherche Scientifique, 34293 Montpellier, France
Akt is classically described as a prosurvival serine/threonine kinase activated in response to trophic factors. After activation by phosphoinositide 3-kinase (PI3-kinase), it can translocate to the nucleus where it promotes specific genetic programs by catalyzing phosphorylation of transcription factors. We report here that both dopamine (DA) D1 (SKF38393) and D2 (quinpirole) agonist treatments rapidly increase, in primary striatal neurons in culture, phosphorylation levels of Akt on Thr308, a residue that is critically involved in its kinase activity. These treatments also activate the extracellular signal-regulated kinase (ERK) pathway in the same population of striatal neurons. Induction of active, phospho-Thr308 Akt by dopamine D1 and D2 agonists is insensitive to wortmannin and thus PI3-kinase independent, in contrast to growth factor-induced Akt activity. D1- and D2-induced phospho-Thr308 Akt is decreased by the mitogen-activated protein kinase kinase (MEK) inhibitor, U0126, as well as by overexpression of a dominant-negative version of MEK, thus implicating the Ras/ERK signaling cascade in this process. Furthermore, overexpression of a mutant form of Akt that cannot be activated impaired cAMP response element-binding protein (CREB) phosphorylation induced by SKF38393 and quinpirole treatments. Activation of Akt on Thr308 was also found in vivo in striatal neurons after acute administration of cocaine, a psychostimulant that strongly increases DA transmission. Thus, multiple intracellular pathways can transduce signals from dopamine receptors to CREB in striatal neurons, one of these being Akt. We propose that this signaling pathway plays a pivotal role in DA-induced regulation of gene expression and long-term neuronal adaptation in the striatum.
Key words: extracellular signal-regulated kinase; phospho-Thr308 Akt; PI3-kinase; cAMP; gene regulation; nuclear translocation; cocaine
Copyright © 2002 Society for Neuroscience 0270-6474/02/22208911-11$05.00/0
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