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The Journal of Neuroscience, October 15, 2002, 22(20):9113-9121
L-Type Voltage-Gated Calcium Channels Are Required for Extinction, But Not for Acquisition or Expression, of Conditional Fear in Mice
Chris K. Cain1, Ashley M. Blouin2, and Mark Barad2, 3 1 Interdepartmental Program in Neuroscience, 2 Department of Psychiatry and Biobehavioral Sciences, and 3 Brain Research Institute and Neuropsychiatric Institute, University of California, Los Angeles, Los Angeles, California 90095
It has been shown recently that extinction of conditional fear does not depend acutely on NMDA-type glutamate receptors, although other evidence has led to the hypothesis that L-type voltage-gated calcium channels (LVGCCs) play a role in conditional fear. We therefore tested the role of LVGCCs in the acquisition, expression, and extinction of conditional fear of cue and context in mice. Using systemic injections of two LVGCC inhibitors, nifedipine and nimodipine, which both effectively cross the blood-brain barrier, we show that LVGCCs are essential for the extinction, but not for the acquisition or expression, of conditional fear in mice.
Key words: fear; acquisition; extinction; expression; freezing; L-type; calcium channel; nifedipine; nimodipine; state dependence
Copyright © 2002 Society for Neuroscience 0270-6474/02/22209113-09$05.00/0
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