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The Journal of Neuroscience, November 1, 2002, 22(21):9155-9159

BRIEF COMMUNICATION
Periadolescent Mice Show Enhanced FosB Upregulation in Response to Cocaine and Amphetamine

Michelle E. Ehrlich^{1, 2}, John Sommer¹, Edwin Canas¹, and Ellen M. Unterwald^{3, 4}

¹ The Nathan Kline Institute, Orangeburg, New York, 10962, ² Departments of Psychiatry and Cell Biology, New York University School of Medicine, New York, New York 10016, ³ Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, and ⁴ The Rockefeller University, New York, New York 10021

Children and adolescents are increasingly exposed to psychostimulants, either illicitly or for the treatment of common neuropsychiatric conditions, such as attention deficit disorder with and without hyperactivity. Despite the widespread use of psychomotor stimulants in younger age groups, little is known regarding the chronic molecular neuroadaptive responses to these agents in the immature brain. Here we demonstrate that, after chronic administration of the psychostimulants cocaine and amphetamine, the transcription factor FosB is upregulated in the nucleus accumbens of periadolescent mice but not in post-weanling or adult mice. Induction of FosB also occurs exclusively in the caudate putamen of periadolescent mice after amphetamine administration. These results demonstrate the unique plasticity in the adolescent brain of a critical molecule that regulates psychostimulant action and suggest that these neuroadaptive changes may be involved in the mediation of enhanced addictive tendencies in the adolescent relative to the adult.

Key words: cocaine; amphetamine; development; FosB; mice; psychostimulants; nucleus accumbens; caudate putamen; periadolescent

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Copyright © 2002 Society for Neuroscience  0270-6474/02/22219155-05$05.00/0

This article has been cited by other articles:

				M. Niculescu, S. A. Perrine, J. S. Miller, M. E. Ehrlich, and E. M. Unterwald Trk: A Neuromodulator of Age-Specific Behavioral and Neurochemical Responses to Cocaine in Mice J. Neurosci., January 30, 2008; 28(5): 1198 - 1207. [Abstract] [Full Text] [PDF]

				D. L. Muller and E. M. Unterwald D1 Dopamine Receptors Modulate {Delta}FosB Induction in Rat Striatum after Intermittent Morphine Administration J. Pharmacol. Exp. Ther., July 1, 2005; 314(1): 148 - 154. [Abstract] [Full Text] [PDF]

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