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The Journal of Neuroscience, December 1, 2002, 22(23):10067-10071

BRIEF COMMUNICATION
Experience-Dependent Coincident Expression of the Effector Immediate-Early Genes Arc and Homer 1a in Hippocampal and Neocortical Neuronal Networks

Almira Vazdarjanova¹, Bruce L. McNaughton^{1, 2}, Carol A. Barnes^{1, 2}, Paul F. Worley³, and John F. Guzowski¹

¹ Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, and ² Departments of Psychology and Neurology, University of Arizona, Tucson, Arizona 85724-5115, and ³ Departments of Neuroscience and Neurology, John Hopkins University, Baltimore, Maryland 21218

The transcription of the immediate-early genes Arc and Homer 1a (H1a) is dynamically regulated in response to synaptic activity; their protein products function at the postsynaptic sites of excitatory synapses. Previous studies demonstrate a role for Arc in the maintenance of long-term potentiation and in memory consolidation processes and indicate a role for H1a in modifying glutamatergic signaling pathways. Using double-label fluorescence in situ hybridization, we demonstrate that Arc and H1a RNA expression is induced strongly in the same neurons of rat hippocampus and neocortex after exploration of a novel environment. These findings support the view that novel experience activates a cell-specific genomic program and that Arc and H1a may function in concert in the structural and functional modifications of dendrites that lead to long-term changes in synaptic efficacy.

Key words: memory; learning; transcription; hippocampus; cortex; immediate-early; gene; Arc; Homer 1; dendrite; plasticity

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Copyright © 2002 Society for Neuroscience  0270-6474/02/222310067-05$05.00/0

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