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The Journal of Neuroscience, December 1, 2002, 22(23):10088-10093

Identification of a Monogenic Locus (jams1) Causing Juvenile Audiogenic Seizures in Mice

Hidemi Misawa^{1, *}, Elliott H. Sherr^{1, 2, *}, David J. Lee¹, Dane M. Chetkovich^{1, 2}, Andrew Tan^{1, 3}, Christoph E. Schreiner^{1, 3}, and David S. Bredt¹

Departments of ¹ Physiology, ² Neurology, and ³ Otolaryngology, University of California at San Francisco, School of Medicine, San Francisco, California 94143-0444

Epilepsy is a debilitating disease with a strong genetic component. Positional cloning has identified a few genes for rare monogenic epilepsy syndromes; however, the genetics of common human epilepsies are too complex to be analyzed easily by current techniques. Mouse models of epilepsy can further this analysis by eliminating genetic background heterogeneity and enabling the production of sufficient numbers of offspring. Here, we report that Black Swiss mice have a heretofore unrecognized specific susceptibility to audiogenic seizures. These seizures are characterized by wild running, loss of righting reflex, and tonic flexion and extension, and are followed by a postictal period. The susceptibility to these seizures is developmentally regulated, peaking at 21 d of age and nearly disappearing by adulthood. Interestingly, both the susceptibility to seizures and their developmental regulation appear unrelated to hearing thresholds in the Black Swiss strain and backcrossed progeny. Genetic mapping and linkage analysis of hybrid mice localize the seizure gene, jams1 (juvenile audiogenic monogenic seizures), to a 1.6 ± 0.5 centimorgan (cM) region on mouse chromosome 10, delimited by the gene basigin (Bsg) and marker D10Mit140. Interestingly, the majority of the critical region is syntenic to a region on human chromosome 19p13.3 implicated in a familial form of juvenile febrile convulsions. Cloning the gene for audiogenic seizures in these mice may provide important insight into the fundamental mechanisms for developmentally regulated human epilepsy syndromes.

Key words: mouse audiogenic seizures; chromosome 10; febrile seizures; chromosome 19p13.3; genetics; developmental regulation; auditory brainstem evoked response

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^* H.M. and E.H.S. contributed equally to this work.

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Copyright © 2002 Society for Neuroscience  0270-6474/02/222310088-06$05.00/0

This article has been cited by other articles:

				H. M. Brew, J. X. Gittelman, R. S. Silverstein, T. D. Hanks, V. P. Demas, L. C. Robinson, C. A. Robbins, J. McKee-Johnson, S. Y. Chiu, A. Messing, et al. Seizures and Reduced Life Span in Mice Lacking the Potassium Channel Subunit Kv1.2, but Hypoexcitability and Enlarged Kv1 Currents in Auditory Neurons J Neurophysiol, September 1, 2007; 98(3): 1501 - 1525. [Abstract] [Full Text] [PDF]

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