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The Journal of Neuroscience, December 15, 2002, 22(24):10838-10846
Efferent Protection from Acoustic Injury Is Mediated via  9
Nicotinic Acetylcholine Receptors on Outer Hair Cells
Stéphane F.
Maison1,
Anne E.
Luebke2,
M. Charles
Liberman1, and
Jian
Zuo3
1 Department of Otology and Laryngology, Harvard
Medical School and Eaton-Peabody Laboratory, Massachusetts Eye and Ear
Infirmary, Boston, Massachusetts 02114, 2 Department of
Otolaryngology and Neuroscience Program, University of Miami School of
Medicine, Miami, Florida 33136, and 3 Department of
Developmental Neurobiology, St. Jude Children's Research Hospital,
Memphis, Tennessee 38105
Exposure to intense sound can damage the mechanosensors of the
inner ear and their afferent innervation. These neurosensory elements
are innervated by a sound-activated feedback pathway, the olivocochlear
efferent system. One major component of this system is cholinergic, and
known cholinergic effects are mediated by the  9/10 nicotinic
acetylcholine receptor (nAChR) complex. Here, we show that
overexpression of 9 nAChR in the outer hair cells of bacterial
artificial chromosome transgenic mice significantly reduces acoustic
injury from exposures causing either temporary or permanent damage,
without changing pre-exposure cochlear sensitivity to low- or
moderate-level sound. These data demonstrate that efferent protection
is mediated via the 9 nAChR in the outer hair cells and provide
direct evidence for a protective role, in vivo, of a
member of the nAChR family.
Key words:
olivocochlear; nicotinic; cholinergic; noise-induced hearing loss; transgenic mouse; cochlea
Copyright © 2002 Society for Neuroscience 0270-6474/02/222410838-09$05.00/0
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