QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (50) Citing Articles via Google Scholar Google Scholar Articles by Ribeiro, S. Articles by Pavlides, C. Search for Related Content PubMed PubMed Citation Articles by Ribeiro, S. Articles by Pavlides, C.

 Previous Article  |  Next Article 

The Journal of Neuroscience, December 15, 2002, 22(24):10914-10923

Induction of Hippocampal Long-Term Potentiation during Waking Leads to Increased Extrahippocampal zif-268 Expression during Ensuing Rapid-Eye-Movement Sleep

Sidarta Ribeiro¹, Claudio V. Mello², Tarciso Velho², Timothy J. Gardner³, Erich D. Jarvis¹, and Constantine Pavlides⁴

¹ Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, ² Neurological Sciences Institute, Oregon Health and Science University, Beaverton, Oregon 97006, and ³ Center for Physics and Biology, and ⁴ Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021

Rapid-eye-movement (REM) sleep plays a key role in the consolidation of memories acquired during waking (WK). The search for mechanisms underlying that role has revealed significant correlations in the patterns of neuronal firing, regional blood flow, and expression of the activity-dependent gene zif-268 between WK and subsequent REM sleep. Zif-268 integrates a major calcium signal transduction pathway and is implicated by several lines of evidence in activity-dependent synaptic plasticity. Here we report that the induction of hippocampal long-term potentiation (LTP) during WK in rats leads to an upregulation of zif-268 gene expression in extrahippocampal regions during subsequent REM sleep episodes. This upregulation occurs predominantly in the amygdala, entorhinal, and auditory cerebral cortices during the first REM sleep episodes after LTP induction and reaches somatosensory and motor cerebral cortices as REM sleep recurs. We also show that hippocampal inactivation during REM sleep blocks extrahippocampal zif-268 upregulation, indicating that cortical and amygdalar zif-268 expression during REM sleep is under hippocampal control. Thus, expression of an activity-dependent gene involved in synaptic plasticity propagates gradually from the hippocampus to extrahippocampal regions as REM sleep recurs. These findings suggest that a progressive disengagement of the hippocampus and engagement of the cerebral cortex and amygdala occurs during REM sleep. They are also consistent with the view that REM sleep constitutes a privileged window for hippocampus-driven cortical activation, which may play an instructive role in the communication of memory traces from the hippocampus to the cerebral cortex.

Key words: REM sleep; zif-268; LTP; learning and memory; immediate-early gene; hippocampus; cerebral cortex; amygdala; plasticity; late sleep; early sleep

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/222410914-10$05.00/0

This article has been cited by other articles:

				J. Best, C. Diniz Behn, G. R. Poe, and V. Booth Neuronal Models for Sleep-Wake Regulation and Synaptic Reorganization in the Sleeping Hippocampus J Biol Rhythms, June 1, 2007; 22(3): 220 - 232. [Abstract] [PDF]

				M. G. Frank and J. H. Benington The Role of Sleep in Memory Consolidation and Brain Plasticity: Dream or Reality? Neuroscientist, December 1, 2006; 12(6): 477 - 488. [Abstract] [PDF]

				P. Shirvalkar, M. Seth, N. D. Schiff, and D. G. Herrera Cognitive enhancement with central thalamic electrical stimulation PNAS, November 7, 2006; 103(45): 17007 - 17012. [Abstract] [Full Text] [PDF]

				M. P. Walker, R. Stickgold, F. A. Jolesz, and S.-S. Yoo The Functional Anatomy of Sleep-dependent Visual Skill Learning Cereb Cortex, November 1, 2005; 15(11): 1666 - 1675. [Abstract] [Full Text] [PDF]

				S. K. Jha, B. E. Jones, T. Coleman, N. Steinmetz, C.-T. Law, G. Griffin, J. Hawk, N. Dabbish, V. A. Kalatsky, and M. G. Frank Sleep-Dependent Plasticity Requires Cortical Activity J. Neurosci., October 5, 2005; 25(40): 9266 - 9274. [Abstract] [Full Text] [PDF]

				R. D. Cartwright The role of sleep in changing our minds: A psychologist's discussion of papers on memory reactivation and consolidation in sleep Learn. Mem., November 1, 2004; 11(6): 660 - 663. [Abstract] [Full Text] [PDF]

				S. Ribeiro and M. A.L. Nicolelis Reverberation, storage, and postsynaptic propagation of memories during sleep Learn. Mem., November 1, 2004; 11(6): 686 - 696. [Abstract] [Full Text] [PDF]

				C.-L. Su, C.-H. Chen, H.-Y. Lu, and P.-W. Gean The Involvement of PTEN in Sleep Deprivation-Induced Memory Impairment in Rats Mol. Pharmacol., November 1, 2004; 66(5): 1340 - 1348. [Abstract] [Full Text] [PDF]

				S. Datta, V. Mavanji, J. Ulloor, and E. H. Patterson Activation of Phasic Pontine-Wave Generator Prevents Rapid Eye Movement Sleep Deprivation-Induced Learning Impairment in the Rat: A Mechanism for Sleep-Dependent Plasticity J. Neurosci., February 11, 2004; 24(6): 1416 - 1427. [Abstract] [Full Text] [PDF]

				H. Miyamoto and T. K. Hensch Reciprocal Interaction of Sleep and Synaptic Plasticity Mol. Interv., October 1, 2003; 3(7): 404 - 417. [Abstract] [Full Text] [PDF]

				P. Maquet, S. Laureys, F. Perrin, P. Ruby, G. Melchior, M. Boly, T. D. Vu, M. Desseilles, and P. Peigneux Festina Lente: Evidences for Fast and Slow Learning Processes and a Role for Sleep in Human Motor Skill Learning Learn. Mem., July 1, 2003; 10(4): 237 - 239. [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help