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The Journal of Neuroscience, 2002, 22:RC204:1-5

RAPID COMMUNICATION
Place-Cell Impairment in Glutamate Receptor 2 Mutant Mice

Jun Yan¹, Yunfeng Zhang¹, Zhenping Jia², Franco A. Taverna³, Robert J. McDonald⁴, Robert U. Muller⁵, and John C. Roder³

¹ Department of Physiology and Biophysics, University of Calgary, Calgary, T2N 4NI Canada , ² Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8 Canada, ³ Division of Development and Fetal Health, Mount Sinai Hospital Research Institute, University of Toronto, Toronto, M5G 1X5 Canada, ⁴ Department of Psychology, University of Toronto, Toronto, M5G 1X5 Canada, and ⁵ Department of Physiology, State University of New York, New York, New York 12246

There is a strong correlation between Hebbian, NMDA receptor-dependent long-term potentiation (LTP), place-cell firing, and learning and memory. We made glutamate receptor 2 (GluR2) null mutant mice that show enhanced non-Hebbian LTP in hippocampal CA1 neurons and impaired performance in a spatial learning task. We concluded that in vivo hippocampal place cells of GluR2 mutant mice were functionally impaired because (1) only 22.6% of CA1 neurons showed place fields in GluR2 mutant mice, which was significantly lower than that (43.8%) in wild-type mice; (2) GluR2 mutant place fields were much less precise; and (3) GluR2 mutant place fields were extremely unstable. Our data suggest that place cells of GluR2 knock-out mice did not form robust place fields, and that enhanced non-Hebbian LTP might play a negative role in their formation.

Key words: hippocampus; place cell; LTP; glutamate receptor; GluR2; knock-out mice

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Copyright © Society for Neuroscience  0270-6474//$05.00/0

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