 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, February 15, 2002, 22(4):1385-1396
Opposite Actions of Brain-Derived Neurotrophic Factor and Neurotrophin-3 on Firing Features and Ion Channel Composition of Murine Spiral Ganglion Neurons
Crista L. Adamson1, *, Michael A. Reid2, *, and Robin L. Davis2 1 W. M. Keck Center for Collaborative Neuroscience and 2 Department of Cell Biology and Neuroscience, Nelson Laboratories, Rutgers University, Piscataway, New Jersey 08854-8082
It is now well established that sensory neurons and receptors display characteristic morphological and electrophysiological properties tailored to their functions. This is especially evident in the auditory system, where cells are arranged tonotopically and are highly specialized for precise coding of frequency- and timing-dependent auditory information. Less well understood, however, are the mechanisms that give rise to these biophysical properties. We have provided insight into this issue by using whole-cell current-clamp recordings and immunocytochemistry to show that BDNF and NT-3, neurotrophins found normally in the cochlea, have profound effects on the firing properties and ion channel distribution of spiral ganglion neurons in the murine cochlea. Exposure of neurons to BDNF caused all neurons, regardless of their original cochlear position, to display characteristics of the basal neurons. Conversely, NT-3 caused cells to show the properties of apical neurons. These results are consistent with oppositely oriented gradients of these two neurotrophins and/or their high-affinity receptors along the tonotopic map, and they suggest that a combination of neurotrophins are necessary to establish the characteristic firing features of postnatal spiral ganglion neurons.
Key words: cochlea; auditory; Kv1.1; Kv3.1; Kv4.2; BK
* C.L.A. and M.A.R. contributed equally to this work.Correspondence should be addressed to Dr. Robin L. Davis, Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, 604 Allison Road, Piscataway, NJ 08854-8082. E-mail: rldavis{at}rci.rutgers.edu.
Copyright © 2002 Society for Neuroscience 0270-6474/02/2241385-12$05.00/0
This article has been cited by other articles:
J. A. Luther and S. J. Birren
p75 and TrkA Signaling Regulates Sympathetic Neuronal Firing Patterns via Differential Modulation of Voltage-Gated Currents
J. Neurosci., April 29, 2009; 29(17): 5411 - 5424.
[Abstract] [Full Text] [PDF]
M. A. D.-L. de Carrizosa, C. J. Morado-Diaz, J. J. Tena, B. Benitez-Temino, M. L. Pecero, S. R. Morcuende, R. R. de la Cruz, and A. M. Pastor
Complementary Actions of BDNF and Neurotrophin-3 on the Firing Patterns and Synaptic Composition of Motoneurons
J. Neurosci., January 14, 2009; 29(2): 575 - 587.
[Abstract] [Full Text] [PDF]
S. Iwasaki, Y. Chihara, Y. Komuta, K. Ito, and Y. Sahara
Low-Voltage-Activated Potassium Channels Underlie the Regulation of Intrinsic Firing Properties of Rat Vestibular Ganglion Cells
J Neurophysiol, October 1, 2008; 100(4): 2192 - 2204.
[Abstract] [Full Text] [PDF]
Z. Jia, J. Bei, L. Rodat-Despoix, B. Liu, Q. Jia, P. Delmas, and H. Zhang
NGF Inhibits M/KCNQ Currents and Selectively Alters Neuronal Excitability in Subsets of Sympathetic Neurons Depending on their M/KCNQ Current Background
J. Gen. Physiol., June 1, 2008; 131(6): 575 - 587.
[Abstract] [Full Text] [PDF]
J. Flores-Otero, H. Z. Xue, and R. L. Davis
Reciprocal Regulation of Presynaptic and Postsynaptic Proteins in Bipolar Spiral Ganglion Neurons by Neurotrophins
J. Neurosci., December 19, 2007; 27(51): 14023 - 14034.
[Abstract] [Full Text] [PDF]
Q. Liu and R. L. Davis
Regional Specification of Threshold Sensitivity and Response Time in CBA/CaJ Mouse Spiral Ganglion Neurons
J Neurophysiol, October 1, 2007; 98(4): 2215 - 2222.
[Abstract] [Full Text] [PDF]
Q. Jia, Z. Jia, Z. Zhao, B. Liu, H. Liang, and H. Zhang
Activation of Epidermal Growth Factor Receptor Inhibits KCNQ2/3 Current through Two Distinct Pathways: Membrane PtdIns(4,5)P2 Hydrolysis and Channel Phosphorylation
J. Neurosci., March 7, 2007; 27(10): 2503 - 2512.
[Abstract] [Full Text] [PDF]
J. A. Luther and S. J. Birren
Nerve Growth Factor Decreases Potassium Currents and Alters Repetitive Firing in Rat Sympathetic Neurons
J Neurophysiol, August 1, 2006; 96(2): 946 - 958.
[Abstract] [Full Text] [PDF]
J. Tan and R. K. Shepherd
Aminoglycoside-Induced Degeneration of Adult Spiral Ganglion Neurons Involves Differential Modulation of Tyrosine Kinase B and p75 Neurotrophin Receptor Signaling
Am. J. Pathol., August 1, 2006; 169(2): 528 - 543.
[Abstract] [Full Text] [PDF]
H. Lang, B. A. Schulte, D. Zhou, N. Smythe, S. S. Spicer, and R. A. Schmiedt
Nuclear factor kappaB deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss.
J. Neurosci., March 29, 2006; 26(13): 3541 - 3550.
[Abstract] [Full Text] [PDF]
Z. Zhou, Q. Liu, and R. L. Davis
Complex Regulation of Spiral Ganglion Neuron Firing Patterns by Neurotrophin-3
J. Neurosci., August 17, 2005; 25(33): 7558 - 7566.
[Abstract] [Full Text] [PDF]
W. A. Hossain, S. D. Antic, Y. Yang, M. N. Rasband, and D. K. Morest
Where Is the Spike Generator of the Cochlear Nerve? Voltage-Gated Sodium Channels in the Mouse Cochlea
J. Neurosci., July 20, 2005; 25(29): 6857 - 6868.
[Abstract] [Full Text] [PDF]
M. A. Reid, J. Flores-Otero, and R. L. Davis
Firing Patterns of Type II Spiral Ganglion Neurons In Vitro
J. Neurosci., January 21, 2004; 24(3): 733 - 742.
[Abstract] [Full Text] [PDF]
R. L. Davis
Gradients of Neurotrophins, Ion Channels, and Tuning in the Cochlea
Neuroscientist, October 1, 2003; 9(5): 311 - 316.
[Abstract] [PDF]
T. Schimmang, J. Tan, M. Muller, U. Zimmermann, K. Rohbock, I. Kopschall, A. Limberger, L. Minichiello, and M. Knipper
Lack of Bdnf and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervation along the tonotopic axis and hearing loss
Development, October 1, 2003; 130(19): 4741 - 4750.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|