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The Journal of Neuroscience, March 1, 2002, 22(5):1823-1830

Long-Term Depression in the Developing Hippocampus: Low Induction Threshold and Synapse Nonspecificity

Pontus Wasling, Eric Hanse, and Bengt Gustafsson

Institute of Physiology and Pharmacology, Göteborg University, SE-405 30 Göteborg, Sweden

It was observed that the use of paired-pulse afferent stimulation as test stimulation (0.1-0.02 Hz) in the hippocampal CA1 area in young (1-2 week) rats, but not in older ones, led to declining synaptic activity. We show that such very low-frequency stimulation leads to long-term depression (LTD) initiated by activation of NMDA receptor channels and/or T-type voltage-dependent calcium channels. The depression is initiated within three or four such stimuli, and <10 are sufficient to induce a notable long-term effect. When the paired-pulse stimulation exceeded threshold for postsynaptic spike activation, the depression was preceded by an NMDA receptor-dependent potentiation. Irrespective of whether homosynaptic potentiation or depression occurred, the paired pulse stimulation also induced depression in neighboring synapses alternately activated by single stimuli. These results point to a very high sensitivity for induction of synaptic depression during the neonatal period. They also support the notion that a brief rise in postsynaptic calcium can induce long-term potentiation (LTP) or LTD, a larger rise more likely to induce LTP, as well as that a prolonged modest increase produces selectively only LTD.

Key words: long-term depression; hippocampus; CA1; heterosynaptic; synaptic plasticity; development

Copyright © 2002 Society for Neuroscience  0270-6474/02/2251823-08$05.00/0


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