 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, March 15, 2002, 22(6):2083-2095
Intrinsic Firing Dynamics of Vestibular Nucleus Neurons
Chris Sekirnjak and Sascha du Lac Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037
Individual brainstem neurons involved in vestibular reflexes respond to identical head movements with a wide range of firing responses. This diversity of firing dynamics has been commonly assumed to arise from differences in the types of vestibular nerve inputs to vestibular nucleus neurons. In this study we show that, independent of the nature of inputs, the intrinsic membrane properties of neurons in the medial vestibular nucleus substantially influence firing response dynamics. Hyperpolarizing and depolarizing inputs evoked a markedly heterogenous range of firing responses. Strong postinhibitory rebound firing (PRF) was associated with strong firing rate adaptation (FRA) and occurred preferentially in large multipolar neurons. In response to sinusoidally modulated input current, these neurons showed a pronounced phase lead with respect to neurons lacking strong PRF and FRA. A combination of the hyperpolarization-activated H current and slow potassium currents contributed to PRF, whereas FRA was predominantly mediated by slow potassium currents. An integrate-and-fire-type model, which simulated FRA and PRF, reproduced the phase lead observed in large neurons and showed that adaptation currents were primarily responsible for variations in response phase. We conclude that the heterogeneity of firing dynamics observed in response to head movements in intact animals reflects intrinsic as well as circuit properties.
Key words: vestibular nucleus neuron; spike frequency adaptation; postinhibitory rebound; IH; potassium current; phase lead
Copyright © 2002 Society for Neuroscience 0270-6474/02/2262083-13$05.00/0
This article has been cited by other articles:
T. M. Hospedales, M. C. W. van Rossum, B. P. Graham, and M. B. Dutia
Implications of noise and neural heterogeneity for vestibulo-ocular reflex fidelity.
Neural Comput., March 1, 2008; 20(3): 756 - 778.
[Abstract] [Full Text] [PDF]
A. Li, J. Xue, and E. H. Peterson
Architecture of the Mouse Utricle: Macular Organization and Hair Bundle Heights
J Neurophysiol, February 1, 2008; 99(2): 718 - 733.
[Abstract] [Full Text] [PDF]
M. V. Podda, M. D'Ascenzo, L. Leone, R. Piacentini, G. B. Azzena, and C. Grassi
Functional role of cyclic nucleotide-gated channels in rat medial vestibular nucleus neurons
J. Physiol., February 1, 2008; 586(3): 803 - 815.
[Abstract] [Full Text] [PDF]
J.-M. Israel, D. A. Poulain, and S. H. R. Oliet
Oxytocin-Induced Postinhibitory Rebound Firing Facilitates Bursting Activity in Oxytocin Neurons
J. Neurosci., January 9, 2008; 28(2): 385 - 394.
[Abstract] [Full Text] [PDF]
A. G. Shaikh, K. Miura, L. M. Optican, S. Ramat, R. J. Leigh, and D. S. Zee
A new familial disease of saccadic oscillations and limb tremor provides clues to mechanisms of common tremor disorders
Brain, November 1, 2007; 130(11): 3020 - 3031.
[Abstract] [Full Text] [PDF]
M. A. A. van der Meer, J. J. Knierim, D. Yoganarasimha, E. R. Wood, and M. C. W. van Rossum
Anticipation in the Rodent Head Direction System Can Be Explained by an Interaction of Head Movements and Vestibular Firing Properties
J Neurophysiol, October 1, 2007; 98(4): 1883 - 1897.
[Abstract] [Full Text] [PDF]
M. Beraneck and K. E. Cullen
Activity of Vestibular Nuclei Neurons During Vestibular and Optokinetic Stimulation in the Alert Mouse
J Neurophysiol, September 1, 2007; 98(3): 1549 - 1565.
[Abstract] [Full Text] [PDF]
A. H. Gittis and S. du Lac
Firing Properties of GABAergic Versus Non-GABAergic Vestibular Nucleus Neurons Conferred by a Differential Balance of Potassium Currents
J Neurophysiol, June 1, 2007; 97(6): 3986 - 3996.
[Abstract] [Full Text] [PDF]
M. W. Bagnall, R. J. Stevens, and S. du Lac
Transgenic Mouse Lines Subdivide Medial Vestibular Nucleus Neurons into Discrete, Neurochemically Distinct Populations
J. Neurosci., February 28, 2007; 27(9): 2318 - 2330.
[Abstract] [Full Text] [PDF]
R. Ramachandran and S. G. Lisberger
Transformation of Vestibular Signals Into Motor Commands in the Vestibuloocular Reflex Pathways of Monkeys
J Neurophysiol, September 1, 2006; 96(3): 1061 - 1074.
[Abstract] [Full Text] [PDF]
A. J. Camp, R. J. Callister, and A. M. Brichta
Inhibitory Synaptic Transmission Differs in Mouse Type A and B Medial Vestibular Nucleus Neurons In Vitro
J Neurophysiol, May 1, 2006; 95(5): 3208 - 3218.
[Abstract] [Full Text] [PDF]
C. Sekirnjak and S. du Lac
Physiological and Anatomical Properties of Mouse Medial Vestibular Nucleus Neurons Projecting to the Oculomotor Nucleus
J Neurophysiol, May 1, 2006; 95(5): 3012 - 3023.
[Abstract] [Full Text] [PDF]
Z. M. Khaliq and I. M. Raman
Axonal Propagation of Simple and Complex Spikes in Cerebellar Purkinje Neurons
J. Neurosci., January 12, 2005; 25(2): 454 - 463.
[Abstract] [Full Text] [PDF]
T. Takazawa, Y. Saito, K. Tsuzuki, and S. Ozawa
Membrane and Firing Properties of Glutamatergic and GABAergic Neurons in the Rat Medial Vestibular Nucleus
J Neurophysiol, November 1, 2004; 92(5): 3106 - 3120.
[Abstract] [Full Text] [PDF]
N. A. Otmakhova and J. E. Lisman
Contribution of Ih and GABAB to Synaptically Induced Afterhyperpolarizations in CA1: A Brake on the NMDA Response
J Neurophysiol, October 1, 2004; 92(4): 2027 - 2039.
[Abstract] [Full Text] [PDF]
N. Fourcaud-Trocme, D. Hansel, C. van Vreeswijk, and N. Brunel
How Spike Generation Mechanisms Determine the Neuronal Response to Fluctuating Inputs
J. Neurosci., December 17, 2003; 23(37): 11628 - 11640.
[Abstract] [Full Text] [PDF]
C. Sekirnjak, B. Vissel, J. Bollinger, M. Faulstich, and S. du Lac
Purkinje Cell Synapses Target Physiologically Unique Brainstem Neurons
J. Neurosci., July 16, 2003; 23(15): 6392 - 6398.
[Abstract] [Full Text] [PDF]
P. Telgkamp and I. M. Raman
Depression of Inhibitory Synaptic Transmission between Purkinje Cells and Neurons of the Cerebellar Nuclei
J. Neurosci., October 1, 2002; 22(19): 8447 - 8457.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|