 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, March 15, 2002, 22(6):2363-2373
Role of Primate Substantia Nigra Pars Reticulata in Reward-Oriented Saccadic Eye Movement
Makoto Sato1, 2 and Okihide Hikosaka1 Departments of 1 Physiology and 2 Neurosurgery, Juntendo University, School of Medicine, Tokyo 113-8421, Japan
To test the hypothesis that the basal ganglia are related to reward-oriented saccades, we examined activity of substantia nigra pars reticulata (SNr) neurons by using a one-direction-rewarded version of the memory-guided saccade task (1DR). Many SNr neurons changed (decreased or increased) their activity after and before a visual cue (post-cue and pre-cue activity). Post-cue decreases or increases tended to be larger to a contralateral cue. They were often modulated prospectively by the presence or absence of reward, either positively (enhanced in the rewarded condition) or negatively (enhanced in the nonrewarded condition). The positive reward modulation was more common among decreasing type neurons, whereas no such preference was observed among increasing type neurons. The reward-contingent decrease in SNr neuronal activity would facilitate rewarded saccades by inducing disinhibition in superior colliculus (SC) neurons. In contrast, the increase in SNr activity would suppress a saccade less selectively (rewarded or nonrewarded) by augmenting inhibition of SC neurons. The post-cue activity was often preceded by anticipatory pre-cue activity. Most typically, post-cue decrease was preceded by pre-cue decrease, selectively when the contralateral side was rewarded. This would reinforce the reward-oriented nature of SNr neuronal activity. The decreases and increases in SNr activity may be derived directly and indirectly, respectively, from the caudate (CD), where neurons show reward-contingent pre-cue and post-cue activity. These results suggest that the CD-SNr-SC mechanism would promote saccades oriented to reward.
Key words: Keywords: basal ganglia; monkey; single-unit recording; memory-guided saccade; motivation; reward expectation
Copyright © 2002 Society for Neuroscience 0270-6474/02/2262363-11$05.00/0
This article has been cited by other articles:
M. Joshua, A. Adler, B. Rosin, E. Vaadia, and H. Bergman
Encoding of Probabilistic Rewarding and Aversive Events by Pallidal and Nigral Neurons
J Neurophysiol, February 1, 2009; 101(2): 758 - 772.
[Abstract] [Full Text] [PDF]
S. Elias, Y. Ritov, and H. Bergman
Balance of Increases and Decreases in Firing Rate of the Spontaneous Activity of Basal Ganglia High-Frequency Discharge Neurons
J Neurophysiol, December 1, 2008; 100(6): 3086 - 3104.
[Abstract] [Full Text] [PDF]
P. Liu and M. A. Basso
Substantia Nigra Stimulation Influences Monkey Superior Colliculus Neuronal Activity Bilaterally
J Neurophysiol, August 1, 2008; 100(2): 1098 - 1112.
[Abstract] [Full Text] [PDF]
K. Nakamura, M. Matsumoto, and O. Hikosaka
Reward-Dependent Modulation of Neuronal Activity in the Primate Dorsal Raphe Nucleus
J. Neurosci., May 14, 2008; 28(20): 5331 - 5343.
[Abstract] [Full Text] [PDF]
F.-W. Zhou, S. G. Matta, and F.-M. Zhou
Constitutively Active TRPC3 Channels Regulate Basal Ganglia Output Neurons
J. Neurosci., January 9, 2008; 28(2): 473 - 482.
[Abstract] [Full Text] [PDF]
T. Ikeda and O. Hikosaka
Positive and Negative Modulation of Motor Response in Primate Superior Colliculus by Reward Expectation
J Neurophysiol, December 1, 2007; 98(6): 3163 - 3170.
[Abstract] [Full Text] [PDF]
A. Nevet, G. Morris, G. Saban, D. Arkadir, and H. Bergman
Lack of Spike-Count and Spike-Time Correlations in the Substantia Nigra Reticulata Despite Overlap of Neural Responses
J Neurophysiol, October 1, 2007; 98(4): 2232 - 2243.
[Abstract] [Full Text] [PDF]
M. A. Basso and P. Liu
Context-Dependent Effects of Substantia Nigra Stimulation on Eye Movements
J Neurophysiol, June 1, 2007; 97(6): 4129 - 4142.
[Abstract] [Full Text] [PDF]
L. Ding and O. Hikosaka
Temporal Development of Asymmetric Reward-Induced Bias in Macaques
J Neurophysiol, January 1, 2007; 97(1): 57 - 61.
[Abstract] [Full Text] [PDF]
R. R. Metzger, N. T. Greene, K. K. Porter, and J. M. Groh
Effects of reward and behavioral context on neural activity in the primate inferior colliculus.
J. Neurosci., July 12, 2006; 26(28): 7468 - 7476.
[Abstract] [Full Text] [PDF]
L. Ding and O. Hikosaka
Comparison of reward modulation in the frontal eye field and caudate of the macaque.
J. Neurosci., June 21, 2006; 26(25): 6695 - 6703.
[Abstract] [Full Text] [PDF]
K. Nakamura and O. Hikosaka
Role of dopamine in the primate caudate nucleus in reward modulation of saccades.
J. Neurosci., May 17, 2006; 26(20): 5360 - 5369.
[Abstract] [Full Text] [PDF]
O. Hikosaka, K. Nakamura, and H. Nakahara
Basal Ganglia Orient Eyes to Reward
J Neurophysiol, February 1, 2006; 95(2): 567 - 584.
[Abstract] [Full Text] [PDF]
J. F. Atherton and M. D. Bevan
Ionic Mechanisms Underlying Autonomous Action Potential Generation in the Somata and Dendrites of GABAergic Substantia Nigra Pars Reticulata Neurons In Vitro
J. Neurosci., September 7, 2005; 25(36): 8272 - 8281.
[Abstract] [Full Text] [PDF]
B. Degos, J.-M. Deniau, A.-M. Thierry, J. Glowinski, L. Pezard, and N. Maurice
Neuroleptic-Induced Catalepsy: Electrophysiological Mechanisms of Functional Recovery Induced by High-Frequency Stimulation of the Subthalamic Nucleus
J. Neurosci., August 17, 2005; 25(33): 7687 - 7696.
[Abstract] [Full Text] [PDF]
D. Arkadir, G. Morris, E. Vaadia, and H. Bergman
Independent Coding of Movement Direction and Reward Prediction by Single Pallidal Neurons
J. Neurosci., November 10, 2004; 24(45): 10047 - 10056.
[Abstract] [Full Text] [PDF]
C. Condy, S. Rivaud-Pechoux, F. Ostendorf, C. J. Ploner, and B. Gaymard
Neural substrate of antisaccades: Role of subcortical structures
Neurology, November 9, 2004; 63(9): 1571 - 1578.
[Abstract] [Full Text] [PDF]
Y. Takikawa, R. Kawagoe, and O. Hikosaka
A Possible Role of Midbrain Dopamine Neurons in Short- and Long-Term Adaptation of Saccades to Position-Reward Mapping
J Neurophysiol, October 1, 2004; 92(4): 2520 - 2529.
[Abstract] [Full Text] [PDF]
T. Wichmann and M. A. Kliem
Neuronal Activity in the Primate Substantia Nigra Pars Reticulata During the Performance of Simple and Memory-Guided Elbow Movements
J Neurophysiol, February 1, 2004; 91(2): 815 - 827.
[Abstract] [Full Text] [PDF]
R. Kawagoe, Y. Takikawa, and O. Hikosaka
Reward-Predicting Activity of Dopamine and Caudate Neurons--A Possible Mechanism of Motivational Control of Saccadic Eye Movement
J Neurophysiol, February 1, 2004; 91(2): 1013 - 1024.
[Abstract] [Full Text] [PDF]
M. R. Roesch and C. R. Olson
Impact of Expected Reward on Neuronal Activity in Prefrontal Cortex, Frontal and Supplementary Eye Fields and Premotor Cortex
J Neurophysiol, September 1, 2003; 90(3): 1766 - 1789.
[Abstract] [Full Text] [PDF]
M. Pare and D. P. Hanes
Controlled Movement Processing: Superior Colliculus Activity Associated with Countermanded Saccades
J. Neurosci., July 23, 2003; 23(16): 6480 - 6489.
[Abstract] [Full Text] [PDF]
H. Itoh, H. Nakahara, O. Hikosaka, R. Kawagoe, Y. Takikawa, and K. Aihara
Correlation of Primate Caudate Neural Activity and Saccade Parameters in Reward-Oriented Behavior
J Neurophysiol, April 1, 2003; 89(4): 1774 - 1783.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|