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The Journal of Neuroscience, April 15, 2002, 22(8):3005-3015
A Developmental Switch of AMPA Receptor Subunits in Neocortical Pyramidal Neurons
Sanjay S. Kumar, Alberto Bacci, Viktor Kharazia, and John R. Huguenard Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305-5122
AMPA receptors mediate most of the fast excitatory neurotransmission in the brain, and those lacking the glutamate receptor 2 (GluR2) subunit are Ca2+-permeable and expressed in cortical structures primarily by inhibitory interneurons. Here we report that synaptic AMPA receptors of excitatory layer 5 pyramidal neurons in the rat neocortex are deficient in GluR2 in early development, approximately before postnatal day 16, as evidenced by their inwardly rectifying current-voltage relationship, blockade of AMPA receptor-mediated EPSCs by external and internal polyamines, permeability to Ca2+, and GluR2 immunoreactivity. Overall, these results indicate that neocortical pyramidal neurons undergo a developmental switch in the Ca2+ permeability of their AMPA receptors through an alteration of their subunit composition. This has important implications for plasticity and neurotoxicity.
Key words: AMPA receptors; GluR2 subunit; Ca2+ permeability; pyramidal neurons; neocortex; developmental switch
Copyright © 2002 Society for Neuroscience 0270-6474/02/2283005-11$05.00/0
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