 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, April 15, 2002, 22(8):3251-3261
Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression
Yukihiko Shirayama, Andrew C.-H. Chen, Shin Nakagawa, David S. Russell, and Ronald S. Duman Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508
Previous studies demonstrated that antidepressant treatment increases the expression of brain-derived neurotrophic factor (BDNF) in rat hippocampus. The present study was conducted to test the hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms. A single bilateral infusion of BDNF into the dentate gyrus of hippocampus produced an antidepressant effect in both the LH and FST that was comparable in magnitude with repeated systemic administration of a chemical antidepressant. These effects were observed as early as 3 d after a single infusion of BDNF and lasted for at least 10 d. Similar effects were observed with neurotrophin-3 (NT-3) but not nerve growth factor. Infusions of BDNF and NT-3 did not influence locomotor activity or passive avoidance. The results provide further support for the hypothesis that BDNF contributes to the therapeutic action of antidepressant treatment.
Key words: neurotrophin-3; nerve growth factor; dentate gyrus; learned helplessness; forced swim test; hippocampus; MAP kinase
Copyright © 2002 Society for Neuroscience 0270-6474/02/2283251-11$05.00/0
This article has been cited by other articles:
S. Chourbaji, M. A. Vogt, F. Fumagalli, R. Sohr, A. Frasca, C. Brandwein, H. Hortnagl, M. A. Riva, R. Sprengel, and P. Gass
AMPA receptor subunit 1 (GluR-A) knockout mice model the glutamate hypothesis of depression
FASEB J, September 1, 2008; 22(9): 3129 - 3134.
[Abstract] [Full Text] [PDF]
J. F. M. Vetencourt, A. Sale, A. Viegi, L. Baroncelli, R. De Pasquale, O. F. O'Leary, E. Castren, and L. Maffei
The Antidepressant Fluoxetine Restores Plasticity in the Adult Visual Cortex
Science, April 18, 2008; 320(5874): 385 - 388.
[Abstract] [Full Text] [PDF]
R.H. Belmaker and G. Agam
Major Depressive Disorder
N. Engl. J. Med., January 3, 2008; 358(1): 55 - 68.
[Full Text] [PDF]
S. Thakker-Varia, J. J. Krol, J. Nettleton, P. M. Bilimoria, D. A. Bangasser, T. J. Shors, I. B. Black, and J. Alder
The Neuropeptide VGF Produces Antidepressant-Like Behavioral Effects and Enhances Proliferation in the Hippocampus
J. Neurosci., November 7, 2007; 27(45): 12156 - 12167.
[Abstract] [Full Text] [PDF]
W. D. Taylor, S. Zuchner, D. R. McQuoid, D. C. Steffens, M. C. Speer, and K. R. R. Krishnan
Allelic Differences in the Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Late-Life Depression
Am J Geriatr Psychiatry, October 1, 2007; 15(10): 850 - 857.
[Abstract] [Full Text] [PDF]
K. Yoshida, H. Higuchi, M. Kamata, H. Takahashi, K. Inoue, T. Suzuki, K. Itoh, and N. Ozaki
The G196A polymorphism of the brain-derived neurotrophic factor gene and the antidepressant effect of milnacipran and fluvoxamine
J Psychopharmacol, August 1, 2007; 21(6): 650 - 656.
[Abstract] [PDF]
J. L. Warner-Schmidt and R. S. Duman
VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants
PNAS, March 13, 2007; 104(11): 4647 - 4652.
[Abstract] [Full Text] [PDF]
J. Fichna, A. Janecka, J. Costentin, and J.-C. Do Rego
The Endomorphin System and Its Evolving Neurophysiological Role
Pharmacol. Rev., March 1, 2007; 59(1): 88 - 123.
[Abstract] [Full Text] [PDF]
R. Hashimoto, T. Numakawa, T. Ohnishi, E. Kumamaru, Y. Yagasaki, T. Ishimoto, T. Mori, K. Nemoto, N. Adachi, A. Izumi, et al.
Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling
Hum. Mol. Genet., October 15, 2006; 15(20): 3024 - 3033.
[Abstract] [Full Text] [PDF]
S. C. Pandey, H. Zhang, A. Roy, and K. Misra
Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors.
J. Neurosci., August 9, 2006; 26(32): 8320 - 8331.
[Abstract] [Full Text] [PDF]
Y. Yagasaki, T. Numakawa, E. Kumamaru, T. Hayashi, T.-P. Su, and H. Kunugi
Chronic Antidepressants Potentiate via Sigma-1 Receptors the Brain-derived Neurotrophic Factor-induced Signaling for Glutamate Release
J. Biol. Chem., May 5, 2006; 281(18): 12941 - 12949.
[Abstract] [Full Text] [PDF]
M. A. Lewis, L. Hunihan, D. Franco, B. Robertson, J. Palmer, D. R. St. Laurent, B. N. Balasubramanian, Y. Li, and R. S. Westphal
Identification and Characterization of Compounds That Potentiate NT-3-Mediated Trk Receptor Activity
Mol. Pharmacol., April 1, 2006; 69(4): 1396 - 1404.
[Abstract] [Full Text] [PDF]
T. Hajszan and N. J. MacLusky
Neurologic links between epilepsy and depression in women: Is hippocampal neuroplasticity the key?
Neurology, March 28, 2006; 66(66_suppl_3): S13 - S22.
[Abstract] [Full Text]
D. Tardito, J. Perez, E. Tiraboschi, L. Musazzi, G. Racagni, and M. Popoli
Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview.
Pharmacol. Rev., March 1, 2006; 58(1): 115 - 134.
[Abstract] [Full Text] [PDF]
M.-K. Sun and D. L. Alkon
Differential Gender-Related Vulnerability to Depression Induction and Converging Antidepressant Responses in Rats
J. Pharmacol. Exp. Ther., February 1, 2006; 316(2): 926 - 932.
[Abstract] [Full Text] [PDF]
X.-Y. Lu, C. S. Kim, A. Frazer, and W. Zhang
Leptin: A potential novel antidepressant
PNAS, January 31, 2006; 103(5): 1593 - 1598.
[Abstract] [Full Text] [PDF]
S. Vaynman and F. Gomez-Pinilla
License to Run: Exercise Impacts Functional Plasticity in the Intact and Injured Central Nervous System by Using Neurotrophins
Neurorehabil Neural Repair, December 1, 2005; 19(4): 283 - 295.
[Abstract] [PDF]
S. Ridder, S. Chourbaji, R. Hellweg, A. Urani, C. Zacher, W. Schmid, M. Zink, H. Hortnagl, H. Flor, F. A. Henn, et al.
Mice with Genetically Altered Glucocorticoid Receptor Expression Show Altered Sensitivity for Stress-Induced Depressive Reactions
J. Neurosci., June 29, 2005; 25(26): 6243 - 6250.
[Abstract] [Full Text] [PDF]
M. Sairanen, G. Lucas, P. Ernfors, M. Castren, and E. Castren
Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus
J. Neurosci., February 2, 2005; 25(5): 1089 - 1094.
[Abstract] [Full Text] [PDF]
D. A. Slattery, S. Desrayaud, and J. F. Cryan
GABAB Receptor Antagonist-Mediated Antidepressant-Like Behavior Is Serotonin-Dependent
J. Pharmacol. Exp. Ther., January 1, 2005; 312(1): 290 - 296.
[Abstract] [Full Text] [PDF]
B. Geller, J. A. Badner, R. Tillman, S. L. Christian, K. Bolhofner, and E. H. Cook Jr.
Linkage Disequilibrium of the Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Children With a Prepubertal and Early Adolescent Bipolar Disorder Phenotype
Am J Psychiatry, September 1, 2004; 161(9): 1698 - 1700.
[Abstract] [Full Text] [PDF]
N. M. Tsankova, A. Kumar, and E. J. Nestler
Histone Modifications at Gene Promoter Regions in Rat Hippocampus after Acute and Chronic Electroconvulsive Seizures
J. Neurosci., June 16, 2004; 24(24): 5603 - 5610.
[Abstract] [Full Text] [PDF]
D. S. Charney and H. K. Manji
Life Stress, Genes, and Depression: Multiple Pathways Lead to Increased Risk and New Opportunities for Intervention
Sci. Signal., March 23, 2004; 2004(225): re5 - re5.
[Abstract] [Full Text] [PDF]
L. Lu, J. Dempsey, S. Y. Liu, J. M. Bossert, and Y. Shaham
A Single Infusion of Brain-Derived Neurotrophic Factor into the Ventral Tegmental Area Induces Long-Lasting Potentiation of Cocaine Seeking after Withdrawal
J. Neurosci., February 18, 2004; 24(7): 1604 - 1611.
[Abstract] [Full Text] [PDF]
C. A. Zarate Jr., J. L. Payne, J. Quiroz, J. Sporn, K. K. Denicoff, D. Luckenbaugh, D. S. Charney, and H. K. Manji
An Open-Label Trial of Riluzole in Patients With Treatment-Resistant Major Depression
Am J Psychiatry, January 1, 2004; 161(1): 171 - 174.
[Abstract] [Full Text] [PDF]
S. S. Newton, E. F. Collier, J. Hunsberger, D. Adams, R. Terwilliger, E. Selvanayagam, and R. S. Duman
Gene Profile of Electroconvulsive Seizures: Induction of Neurotrophic and Angiogenic Factors
J. Neurosci., November 26, 2003; 23(34): 10841 - 10851.
[Abstract] [Full Text] [PDF]
L. Santarelli, M. Saxe, C. Gross, A. Surget, F. Battaglia, S. Dulawa, N. Weisstaub, J. Lee, R. Duman, O. Arancio, et al.
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
Science, August 8, 2003; 301(5634): 805 - 809.
[Abstract] [Full Text] [PDF]
Y. Dwivedi, H. S. Rizavi, R. R. Conley, R. C. Roberts, C. A. Tamminga, and G. N. Pandey
Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects
Arch Gen Psychiatry, August 1, 2003; 60(8): 804 - 815.
[Abstract] [Full Text] [PDF]
T. Saarelainen, P. Hendolin, G. Lucas, E. Koponen, M. Sairanen, E. MacDonald, K. Agerman, A. Haapasalo, H. Nawa, R. Aloyz, et al.
Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects
J. Neurosci., January 1, 2003; 23(1): 349 - 357.
[Abstract] [Full Text] [PDF]
S. S. Newton, J. Thome, T. L. Wallace, Y. Shirayama, L. Schlesinger, N. Sakai, J. Chen, R. Neve, E. J. Nestler, and R. S. Duman
Inhibition of cAMP Response Element-Binding Protein or Dynorphin in the Nucleus Accumbens Produces an Antidepressant-Like Effect
J. Neurosci., December 15, 2002; 22(24): 10883 - 10890.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|