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The Journal of Neuroscience, May 1, 2002, 22(9):3326-3331

MINI REVIEW
Cannabinoid Addiction: Behavioral Models and Neural Correlates

Rafael Maldonado¹ and Fernando Rodríguez de Fonseca²

¹ Laboratori de Neurofarmacologia, Facultat de Cienciés de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain, and ² Fundación Hospital Carlos Haya, Unidad de Investigación, 29010 Málaga, Spain

The use of cannabis sativa preparations as recreational drugs can be traced back to the earliest civilizations. However, animal models of cannabinoid addiction allowing the exploration of neural correlates of cannabinoid abuse have been developed only recently. We review these models and the role of the CB1 cannabinoid receptor, the main target of natural cannabinoids, and its interaction with opioid and dopamine transmission in reward circuits. Extensive reviews on the molecular basis of cannabinoid action are available elsewhere (Piomelli et al., 2000; Schlicker and Kathmann, 2001).

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Copyright © 2002 Society for Neuroscience  0270-6474/02/2293326-06$05.00/0

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