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This article has been retracted

The Journal of Neuroscience, May 1, 2002, 22(9):3386-3391

Hydrogen Sulfide Is Produced in Response to Neuronal Excitation

Ko Eto, Miki Ogasawara, Ken Umemura, Yasuo Nagai, and Hideo Kimura

National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan

Although hydrogen sulfide (H₂S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain. Physiological concentrations of H₂S selectively enhance NMDA receptor-mediated responses and alter the induction of hippocampal long-term potentiation (LTP). Here we use cystathionine -synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H₂S in the brain and that H₂S production is greatly enhanced by the excitatory neurotransmitter L-glutamate, as well as by electrical stimulation. This increased CBS activity is regulated by a pathway involving Ca²⁺/calmodulin. In addition, LTP is altered in CBS knock-out mice. These observations suggest that H₂S is produced by CBS in response to neuronal excitation and that it may regulate some aspects of synaptic activity.

Key words: hydrogen sulfide; neuromodulator; calcium ion; calmodulin; neuronal excitation; glutamate; LTP

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Copyright © 2002 Society for Neuroscience  0270-6474/02/2293386-06$05.00/0

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