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The Journal of Neuroscience, May 1, 2002, 22(9):3628-3637

A Hippocampal NR2B Deficit Can Mimic Age-Related Changes in Long-Term Potentiation and Spatial Learning in the Fischer 344 Rat

Daniel A. Clayton^{1, 2}, Michael H. Mesches^{2, 3, 4}, Enriquez Alvarez^{1, 2}, Paula C. Bickford^{5, 6}, and Michael D. Browning^{2, 3}

¹ Medical Scientist Training Program, ² Neuroscience Program, and ³ Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, 80262, ⁴ Veterans Affairs Medical Center, Denver, Colorado 80220, ⁵ James A. Haley Veterans Affairs Medical Center, Tampa, Florida 33612, and ⁶ Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, Tampa, Florida 33169

Aged rats are known to have deficits in spatial learning behavior in the Morris water maze. We have found that aged rats also have deficits in NR2B protein expression and that the protein expression deficit is correlated with their performance in the Morris water maze. To test whether this NR2B deficit was sufficient to account for the behavioral deficit, we used antisense oligonucleotides to specifically knock down NR2B subunit expression in the hippocampus of young rats. NR2B antisense treatment diminished NMDA receptor responses, abolished NMDA-dependent long-term potentiation (LTP), and impaired spatial learning. These data demonstrate the important role of NR2B in LTP and learning and memory and suggest a role for reduced NR2B expression in age-related cognitive decline.

Key words: NMDA; NR2B; aging; LTP; learning; antisense

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Copyright © 2002 Society for Neuroscience  0270-6474/02/2293628-10$05.00/0

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