 |
 Previous Article | Next Article 
The Journal of Neuroscience, May 1, 2002, 22(9):3638-3644
Overcoming the Effects of Stress on Synaptic Plasticity in the
Intact Hippocampus: Rapid Actions of Serotonergic and Antidepressant
Agents
Alison C.
Shakesby1,
Roger
Anwyl2, and
Michael
J.
Rowan1
Departments of 1 Pharmacology and Therapeutics and
2 Physiology, Trinity College, Dublin 2, Ireland
Acute inescapable stress dramatically affects the inducibility of
plasticity at glutamatergic synapses in the intact hippocampus. The
present study examined the involvement of serotonergic mechanisms in
mediating and modulating the block of long-term potentiation (LTP) in
the CA1 area of anesthetized rats after exposure to an elevated
platform stress. Fluoxetine and fenfluramine, agents that raise
hippocampal extracellular 5-HT concentration, blocked the induction of
LTP in nonstressed animals, thus mimicking the effect of stress. In
contrast, (±)-tianeptine, a drug that decreases 5-HT levels, had no
effect on LTP induction in nonstressed animals. Remarkably, (±)
administration of tianeptine after the stress rapidly overcame the
block of LTP induction without affecting baseline excitatory
transmission. Consistent with a reduction of 5-HT levels being
responsible for this effect of tianeptine, the ( ) enantiomer, which
is associated with the 5-HT uptake enhancing action of (±)-tianeptine,
also caused a recovery of the induction of LTP in previously stressed
animals, whereas the relatively inactive (+) enantiomer had no effect.
Furthermore, fluoxetine prevented the effect of tianeptine in stressed
animals. These findings show that antidepressants have rapid and
powerful interactions with the mechanisms controlling the persistence
of the block of LTP by inescapable stress.
Key words:
acute stress; synaptic plasticity; long-term
potentiation; 5-hydroxytryptamine; fluoxetine; fenfluramine; tianeptine; in vivo; antidepressant
Copyright © 2002 Society for Neuroscience 0270-6474/02/2293638-07$05.00/0
This article has been cited by other articles:
|
|
|
|
 
O. Bukalo, M. Schachner, and A. Dityatev
Hippocampal Metaplasticity Induced by Deficiency in the Extracellular Matrix Glycoprotein Tenascin-R
J. Neurosci.,
May 30, 2007;
27(22):
6019 - 6028.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Wilson, S. E. Arnold, J. A. Schneider, Y. Li, and D. A. Bennett
Chronic Distress, Age-Related Neuropathology, and Late-Life Dementia
Psychosom Med,
January 1, 2007;
69(1):
47 - 53.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. MILLER and B. S. MCEWEN
Establishing an Agenda for Translational Research on PTSD
Ann. N.Y. Acad. Sci.,
July 1, 2006;
1071(1):
294 - 312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Tachibana, M. Matsumoto, H. Koseki, H. Togashi, T. Kojima, Y. Morimoto, and M. Yoshioka
Electrophysiological and neurochemical characterization of the effect of repeated treatment with milnacipran on the rat serotonergic and noradrenergic systems
J Psychopharmacol,
July 1, 2006;
20(4):
562 - 569.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. Bonanno, R. Giambelli, L. Raiteri, E. Tiraboschi, S. Zappettini, L. Musazzi, M. Raiteri, G. Racagni, and M. Popoli
Chronic Antidepressants Reduce Depolarization-Evoked Glutamate Release and Protein Interactions Favoring Formation of SNARE Complex in Hippocampus
J. Neurosci.,
March 30, 2005;
25(13):
3270 - 3279.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. J. CARROLL
Untreated Depression and Hippocampal Volume Loss
Am J Psychiatry,
July 1, 2004;
161(7):
1309 - 1310.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tan, P. Zhong, and Z. Yan
Corticotropin-Releasing Factor and Acute Stress Prolongs Serotonergic Regulation of GABA Transmission in Prefrontal Cortical Pyramidal Neurons
J. Neurosci.,
May 26, 2004;
24(21):
5000 - 5008.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. P. Reagan, D. R. Rosell, G. E. Wood, M. Spedding, C. Munoz, J. Rothstein, and B. S. McEwen
Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: Reversal by tianeptine
PNAS,
February 17, 2004;
101(7):
2179 - 2184.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Rocher, M. Spedding, C. Munoz, and T. M. Jay
Acute Stress-induced Changes in Hippocampal/Prefrontal Circuits in Rats: Effects of Antidepressants
Cereb Cortex,
February 1, 2004;
14(2):
224 - 229.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Wilson, D. A. Evans, J. L. Bienias, C. F. Mendes de Leon, J. A. Schneider, and D. A. Bennett
Proneness to psychological distress is associated with risk of Alzheimer's disease
Neurology,
December 9, 2003;
61(11):
1479 - 1485.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Woodson, D. Macintosh, M. Fleshner, and D. M. Diamond
Emotion-Induced Amnesia in Rats: Working Memory-Specific Impairment, Corticosterone-Memory Correlation, and Fear Versus Arousal Effects on Memory
Learn. Mem.,
September 1, 2003;
10(5):
326 - 336.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Korz and J. U. Frey
Stress-Related Modulation of Hippocampal Long-Term Potentiation in Rats: Involvement of Adrenal Steroid Receptors
J. Neurosci.,
August 13, 2003;
23(19):
7281 - 7287.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
