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The Journal of Neuroscience, May 1, 2002, 22(9):3831-3843
The Diversity of Ganglion Cells in a Mammalian Retina
Rebecca L.
Rockhill,
Frank J.
Daly,
Margaret A.
MacNeil,
Solange P.
Brown, and
Richard H.
Masland
Howard Hughes Medical Institute, Massachusetts General Hospital,
Harvard Medical School, Boston, Massachusetts 02114
We report a survey of the population of ganglion cells in the
rabbit retina. A random sample of 301 neurons in the ganglion cell
layer was targeted for photofilling, a method in which the arbors of
the chosen neurons are revealed by diffusion of a photochemically induced fluorescent product from their somas. An additional 129 cells
were labeled by microinjection of Lucifer yellow. One hundred and
thirty-eight cells were visualized by expression of the gene encoding a
green fluorescent protein, introduced by particle-mediated gene
transfer. One hundred and sixty-six cells were labeled by particle-mediated introduction of DiI. In the total population of 734 neurons, we could identify 11 types of retinal ganglion cell. An
analysis based on retinal coverage shows that this number of ganglion
cell types would not exceed the available total number of ganglion
cells. Although some uncertainties remain, this sample appears to
account for the majority of the ganglion cells present in the rabbit
retina. Some known physiological types could easily be mapped onto
structural types, but half of them could not; a large set of poorly
known codings of the visual input is transmitted to the brain.
Key words:
anatomy; green fluorescent protein; photofill; gene gun; neuron; photochemistry
Copyright © 2002 Society for Neuroscience 0270-6474/02/2293831-13$05.00/0
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