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The Journal of Neuroscience, January 1, 2003, 23(1):17-22

BRIEF COMMUNICATION
The Hippocampus Plays an Important Role in Eyeblink Conditioning with a Short Trace Interval in Glutamate Receptor Subunit 2 Mutant Mice

Kanako Takatsuki¹, Shigenori Kawahara^{1, 3}, Sadaharu Kotani¹, Satoshi Fukunaga¹, Hisashi Mori², Masayoshi Mishina², and Yutaka Kirino¹

¹ Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan, ² Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, The University of Tokyo, and Solution Oriented Research for Science and Technology, Japan Science and Technology Corporation, Tokyo 113-0033, Japan, and ³ Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Saitama 332-0012, Japan

Mutant mice lacking the glutamate receptor subunit 2 exhibit changes in the structure and function of the cerebellar cortex. The most prominent functional feature is a deficiency in the long-term depression (LTD) at parallel fiber-Purkinje cell synapses. These mutant mice exhibit severe impairment during delay eyeblink conditioning but learn normally during trace eyeblink conditioning without the cerebellar LTD, even with a 0 trace interval. We investigated the hippocampal contribution to this cerebellar LTD-independent "0 trace interval" learning. The mutant mice whose dorsal hippocampi were aspirated exhibited severe impairment in learning, whereas those that received post-training hippocampal lesions retained the memory. The wild-type mice showed no impairment in either case. These results suggest that the hippocampal component of the eyeblink conditioning task becomes dominant when cerebellar LTD is impaired.

Key words: classical conditioning; eyeblink; hippocampus; cerebellum; long-term depression; mouse

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Copyright © 2003 Society for Neuroscience  0270-6474/03/23117-06$05.00/0

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