QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (35) Citing Articles via Google Scholar Google Scholar Articles by Shu, T. Articles by Richards, L. J. Search for Related Content PubMed PubMed Citation Articles by Shu, T. Articles by Richards, L. J.

 Previous Article  |  Next Article 

The Journal of Neuroscience, January 1, 2003, 23(1):203-212

Abnormal Development of Forebrain Midline Glia and Commissural Projections in Nfia Knock-Out Mice

Tianzhi Shu¹, Kenneth G. Butz², Celine Plachez¹, Richard M. Gronostajski², and Linda J. Richards¹

¹ Department of Anatomy and Neurobiology, and the Program in Neuroscience, The University of Maryland, Baltimore, School of Medicine, Baltimore, Maryland 21201, and ² Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, and Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44195

Nuclear factor I (NFI) genes are expressed in multiple organs throughout development (Chaudhry et al., 1997; for review, see Gronostajski, 2000). All four NFI genes are expressed in embryonic mouse brain, with Nfia, Nfib, and Nfix being expressed highly in developing cortex (Chaudhry et al., 1997). Disruption of the Nfia gene causes agenesis of the corpus callosum (ACC), hydrocephalus, and reduced GFAP expression (das Neves et al., 1999). Three midline structures, the glial wedge, glia within the indusium griseum, and the glial sling are involved in development of the corpus callosum (Silver et al., 1982; Silver and Ogawa, 1983; Shu and Richards, 2001). Because Nfia^/ mice show glial abnormalities and ACC, we asked whether defects in midline glial structures occur in Nfia^/ mice. NFI-A protein is expressed in all three midline populations. In Nfia^/, mice sling cells are generated but migrate abnormally into the septum and do not form a sling. Glia within the indusium griseum and the glial wedge are greatly reduced or absent and consequently Slit2 expression is also reduced. Although callosal axons approach the midline, they fail to cross and extend aberrantly into the septum. The hippocampal commissure is absent or reduced, whereas the ipsilaterally projecting perforating axons (Hankin and Silver, 1988; Shu et al., 2001) appear relatively normal. These results support an essential role for midline glia in callosum development and a role for Nfia in the formation of midline glial structures.

Key words: glial wedge; glial sling; glial tunnel; corpus callosum; anterior commissure; hippocampal commissure; Slit2

---

Copyright © 2003 Society for Neuroscience  0270-6474/03/231203-10$05.00/0

This article has been cited by other articles:

				W. Wang, D. Mullikin-Kilpatrick, J. E. Crandall, R. M. Gronostajski, E. D. Litwack, and D. L. Kilpatrick Nuclear Factor I Coordinates Multiple Phases of Cerebellar Granule Cell Development via Regulation of Cell Adhesion Molecules J. Neurosci., June 6, 2007; 27(23): 6115 - 6127. [Abstract] [Full Text] [PDF]

				K. Driller, A. Pagenstecher, M. Uhl, H. Omran, A. Berlis, A. Grunder, and A. E. Sippel Nuclear Factor I X Deficiency Causes Brain Malformation and Severe Skeletal Defects Mol. Cell. Biol., May 15, 2007; 27(10): 3855 - 3867. [Abstract] [Full Text] [PDF]

				H.-S. Chang, M. D. Anway, S. S. Rekow, and M. K. Skinner Transgenerational Epigenetic Imprinting of the Male Germline by Endocrine Disruptor Exposure during Gonadal Sex Determination Endocrinology, December 1, 2006; 147(12): 5524 - 5541. [Abstract] [Full Text] [PDF]

				S. M. Gopalan, K. M. Wilczynska, B. S. Konik, L. Bryan, and T. Kordula Nuclear Factor-1-X Regulates Astrocyte-specific Expression of the {alpha}1-Antichymotrypsin and Glial Fibrillary Acidic Protein Genes J. Biol. Chem., May 12, 2006; 281(19): 13126 - 13133. [Abstract] [Full Text] [PDF]

				B. C. Yaden, M. Garcia III, T. P. L. Smith, and S. J. Rhodes Two Promoters Mediate Transcription from the Human LHX3 Gene: Involvement of Nuclear Factor I and Specificity Protein 1 Endocrinology, January 1, 2006; 147(1): 324 - 337. [Abstract] [Full Text] [PDF]

				M. J. F. Barresi, L. D. Hutson, C.-B. Chien, and R. O. Karlstrom Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain Development, August 15, 2005; 132(16): 3643 - 3656. [Abstract] [Full Text] [PDF]

				H. Xu, J. K. Uno, M. Inouye, J. F. Collins, and F. K. Ghishan NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene Am J Physiol Gastrointest Liver Physiol, February 1, 2005; 288(2): G175 - G181. [Abstract] [Full Text] [PDF]

				G. Steele-Perkins, C. Plachez, K. G. Butz, G. Yang, C. J. Bachurski, S. L. Kinsman, E. D. Litwack, L. J. Richards, and R. M. Gronostajski The Transcription Factor Gene Nfib Is Essential for both Lung Maturation and Brain Development Mol. Cell. Biol., January 15, 2005; 25(2): 685 - 698. [Abstract] [Full Text] [PDF]

				W. Wang, R. E. Stock, R. M. Gronostajski, Y. W. Wong, M. Schachner, and D. L. Kilpatrick A Role for Nuclear Factor I in the Intrinsic Control of Cerebellar Granule Neuron Gene Expression J. Biol. Chem., December 17, 2004; 279(51): 53491 - 53497. [Abstract] [Full Text] [PDF]

				T. Shu, Y. Li, A. Keller, and L. J. Richards The glial sling is a migratory population of developing neurons Development, July 1, 2003; 130(13): 2929 - 2937. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help