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The Journal of Neuroscience, June 1, 2003, 23(11):4645-4656

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The Distribution of Climbing and Mossy Fiber Collateral Branches from the Copula Pyramidis and the Paramedian Lobule: Congruence of Climbing Fiber Cortical Zones and the Pattern of Zebrin Banding within the Rat Cerebellum

Jan Voogd,² Joanne Pardoe,¹ Tom J. H. Ruigrok,² and Richard Apps¹

¹ Department of Physiology, University of Bristol, BS8 1TD Bristol, United Kingdom, and ² Department of Neuroscience, Erasmus MC, 3000 DR Rotterdam, The Netherlands

Individual cerebellar cortical zones defined by the somatotopy of climbing fiber responses and by their olivo-cortico-nuclear connections located in the paramedian lobule and the copula pyramidis of the rat cerebellum were microinjected with cholera toxin B subunit. Collateral branches of climbing and mossy fibers were mapped and related to the pattern of zebrin-positive and -negative bands of Purkinje cells. Climbing fiber collaterals from the copula distribute to the anterior lobe: from the paramedian lobule mainly to lobulus simplex and rostral crus I. Climbing fibers terminating in particular zones (X, A₂, C₁, C_X, C₂, C₃, D₁, and D₂) in the paramedian lobule or the copula collateralize to one or two corresponding zones in lobulus simplex, crus I and II, the paraflocculus, and/or the anterior lobe. These zones can be defined by their relationship to the pattern of zebrin banding. Collaterals from mossy fibers, labeled from the same injection sites in the copula and paramedian lobule, often distribute bilaterally in a symmetrical pattern of multiple but ill-defined longitudinal strips in the anterior lobe and/or lobulus simplex. One or more of these longitudinal aggregates of mossy fiber collaterals was always found subjacent to the strip(s) of labeled climbing fiber collaterals arising from the same locus in the paramedian lobule or the copula. Corticonuclear projections focused on the target nucleus of each zone, although a bilateral plexus of thinner axons, presumably of mossy fiber collateral origin, was sometimes also present in several other regions of the cerebellar nuclei. Overall, these results suggest that climbing fiber zones and zebrin banding reflect a common organizational scheme within the cerebellar cortex.

Key words: cerebellum; cholera toxin B unit; climbing fiber collaterals; mossy fiber collaterals; zebrin pattern; zonal organization

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Received Jul. 19, 2002; revised Feb. 27, 2003; accepted Mar. 11, 2003.

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