WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, June 1, 2003, 23(11):4726-4736

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (56)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Caplan, J. B.
Right arrow Articles by Kahana, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Caplan, J. B.
Right arrow Articles by Kahana, M. J.

 Previous Article  |  Next Article 

Human {theta} Oscillations Related to Sensorimotor Integration and Spatial Learning

Jeremy B. Caplan,1 Joseph R. Madsen,2,3 Andreas Schulze-Bonhage,4 Richard Aschenbrenner-Scheibe,4 Ehren L. Newman,1 and Michael J. Kahana1,2

1 Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, 2 Department of Neurosurgery, Children's Hospital, Boston, Massachusetts 02115, 3 Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, and 4 Neurozentrum, Universität Freiburg, 79106 Freiburg, Germany

{theta} oscillations in the rat hippocampus have been implicated in sensorimotor integration (Bland, 1986), especially during exploratory and wayfinding behavior. We propose that human cortical {theta} activity coordinates sensory information with a motor plan to guide wayfinding behavior to known goal locations. To test this hypothesis, we analyzed invasive recordings from epileptic patients while they performed a spatially immersive, virtual taxi driver task. Consistent with this hypothesis, we found {theta} oscillations during both exploratory search and goal-seeking behavior and, in particular, during virtual movement, when sensory information and motor planning were both in flux, compared with periods of self-initiated stillness. {theta} oscillations had different topographic and spectral characteristics during searching than during goal-seeking, suggesting that different cortical networks exhibit {theta} depending on which cognitive functions are driving behavior (spatial learning during exploration vs orienting to a learned representation during goal-seeking). In contrast, oscillations in the {beta} band appeared to be related to simple motor planning, likely a variant of the Rolandic µ rhythm. These findings suggest that human cortical {theta} oscillations act to coordinate sensory and motor brain activity in various brain regions to facilitate exploratory learning and navigational planning.

Key words: {theta} oscillations; intracranial electroencephalography; spatial navigation; spatial memory; sensorimotor integration; wayfinding

Received Oct. 28, 2002; revised Feb. 21, 2003; accepted Mar. 5, 2003.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
A. Ekstrom, N. Suthana, D. Millett, I. Fried, and S. Bookheimer
Correlation Between BOLD fMRI and Theta-Band Local Field Potentials in the Human Hippocampal Area
J Neurophysiol, May 1, 2009; 101(5): 2668 - 2678.
[Abstract] [Full Text] [PDF]

Home page
 Psychon Bull RevHome page
C. T. Weidemann, M. V. Mollison, and M. J. Kahana
Electrophysiological correlates of high-level perception during spatial navigation
Psychon Bull Rev, April 1, 2009; 16(2): 313 - 319.
[Abstract] [PDF]

Home page
 BrainHome page
N. Axmacher, C. E. Elger, and J. Fell
Ripples in the medial temporal lobe are relevant for human memory consolidation
Brain, July 1, 2008; 131(7): 1806 - 1817.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. R. Cornwell, L. L. Johnson, T. Holroyd, F. W. Carver, and C. Grillon
Human Hippocampal and Parahippocampal Theta during Goal-Directed Spatial Navigation Predicts Performance on a Virtual Morris Water Maze
J. Neurosci., June 4, 2008; 28(23): 5983 - 5990.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Hajos, C. J. Siok, W. E. Hoffmann, S. Li, and B. Kocsis
Modulation of Hippocampal Theta Oscillation by Histamine H3 Receptors
J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 391 - 398.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
J. B. Caplan, A. R. McIntosh, and E. De Rosa
Two Distinct Functional Networks for Successful Resolution of Proactive Interference
Cereb Cortex, July 1, 2007; 17(7): 1650 - 1663.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Fan, J. Byrne, M. S. Worden, K. G. Guise, B. D. McCandliss, J. Fossella, and M. I. Posner
The Relation of Brain Oscillations to Attentional Networks
J. Neurosci., June 6, 2007; 27(23): 6197 - 6206.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Raghavachari, J. E. Lisman, M. Tully, J. R. Madsen, E. B. Bromfield, and M. J. Kahana
Theta Oscillations in Human Cortex During a Working-Memory Task: Evidence for Local Generators
J Neurophysiol, March 1, 2006; 95(3): 1630 - 1638.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. J. Kahana
The Cognitive Correlates of Human Brain Oscillations
J. Neurosci., February 8, 2006; 26(6): 1669 - 1672.
[Full Text] [PDF]

Home page
 Chem SensesHome page
A. Kepecs, N. Uchida, and Z. F. Mainen
The Sniff as a Unit of Olfactory Processing
Chem Senses, February 1, 2006; 31(2): 167 - 179.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. T. Dypvik and B. H. Bland
Functional Connectivity Between the Red Nucleus and the Hippocampus Supports the Role of Hippocampal Formation in Sensorimotor Integration
J Neurophysiol, October 1, 2004; 92(4): 2040 - 2050.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Cacucci, C. Lever, T. J. Wills, N. Burgess, and J. O'Keefe
Theta-Modulated Place-by-Direction Cells in the Hippocampal Formation in the Rat
J. Neurosci., September 22, 2004; 24(38): 8265 - 8277.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. B. Sederberg, M. J. Kahana, M. W. Howard, E. J. Donner, and J. R. Madsen
Theta and Gamma Oscillations during Encoding Predict Subsequent Recall
J. Neurosci., November 26, 2003; 23(34): 10809 - 10814.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. L. Cantero, M. Atienza, R. Stickgold, M. J. Kahana, J. R. Madsen, and B. Kocsis
Sleep-Dependent {theta} Oscillations in the Human Hippocampus and Neocortex
J. Neurosci., November 26, 2003; 23(34): 10897 - 10903.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-