QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, June 15, 2003, 23(12):5302-5307

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (57) Citing Articles via Google Scholar Google Scholar Articles by Maguire, E. A. Articles by Frith, C. D. Search for Related Content PubMed PubMed Citation Articles by Maguire, E. A. Articles by Frith, C. D.

 Previous Article  |  Next Article 

Lateral Asymmetry in the Hippocampal Response to the Remoteness of Autobiographical Memories

Eleanor A. Maguire and Christopher D. Frith

Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom

The time scale of hippocampal involvement in retrieving memories, particularly those more remote, is still a matter of debate. Some propose that the hippocampus is not involved in the retrieval of remote memories, whereas others assert that it is necessary for memory retrieval in perpetuity. Functional magnetic resonance imaging was used to examine the effect of remoteness on the neural basis of memory. We used a parametric event-related random-effects design in a large group of subjects to overcome some of the limitations of previous neuroimaging studies. We found that the hippocampi were significantly active during the retrieval of autobiographical memories. Notably, the two hippocampi diverged in their responses to remoteness. The right hippocampus showed a temporal gradient, decreasing in activity the more remote the autobiographical memories. No such effect was apparent in the left hippocampus, suggesting its invariant involvement in remembering autobiographical events throughout the lifespan. The dorsal amygdalas showed a temporal gradient similar to the right hippocampus, but emotional valence and intensity were not directly associated with changes in activity. The current results indicate that consideration of lateral asymmetry may help to broaden the scope of theoretical interpretations concerning hippocampal involvement in remote memory.

Key words: fMRI; hippocampus; temporal gradient; consolidation; episodic memory; amygdala

---

Received Nov. 4, 2002; revised Mar. 31, 2003; accepted Mar. 31, 2003.

This article has been cited by other articles:

				J. R. Binder, R. H. Desai, W. W. Graves, and L. L. Conant Where Is the Semantic System? A Critical Review and Meta-Analysis of 120 Functional Neuroimaging Studies Cereb Cortex, December 1, 2009; 19(12): 2767 - 2796. [Abstract] [Full Text] [PDF]

				E. Svoboda and B. Levine The Effects of Rehearsal on the Functional Neuroanatomy of Episodic Autobiographical and Semantic Remembering: A Functional Magnetic Resonance Imaging Study J. Neurosci., March 11, 2009; 29(10): 3073 - 3082. [Abstract] [Full Text] [PDF]

				C. N. Smith and L. R. Squire Medial Temporal Lobe Activity during Retrieval of Semantic Memory Is Related to the Age of the Memory J. Neurosci., January 28, 2009; 29(4): 930 - 938. [Abstract] [Full Text] [PDF]

				S. M. Daselaar, H. J. Rice, D. L. Greenberg, R. Cabeza, K. S. LaBar, and D. C. Rubin The Spatiotemporal Dynamics of Autobiographical Memory: Neural Correlates of Recall, Emotional Intensity, and Reliving Cereb Cortex, January 1, 2008; 18(1): 217 - 229. [Abstract] [Full Text] [PDF]

				A. Viard, P. Piolino, B. Desgranges, G. Chetelat, K. Lebreton, B. Landeau, A. Young, V. De La Sayette, and F. Eustache Hippocampal Activation for Autobiographical Memories over the Entire Lifetime in Healthy Aged Subjects: An fMRI Study Cereb Cortex, October 1, 2007; 17(10): 2453 - 2467. [Abstract] [Full Text] [PDF]

				D. R. Addis, M. Moscovitch, and M. P. McAndrews Consequences of hippocampal damage across the autobiographical memory network in left temporal lobe epilepsy Brain, September 1, 2007; 130(9): 2327 - 2342. [Abstract] [Full Text] [PDF]

				B. E. Harrison, B. A. Therrien, and B. J. Giordani Alzheimer's disease behaviors from past self-identities: An exploration of the memory and cognitive features American Journal of Alzheimer's Disease and Other Dementias, July 1, 2005; 20(4): 248 - 254. [Abstract] [PDF]

				A. V. Samsonovich and G. A. Ascoli A simple neural network model of the hippocampus suggesting its pathfinding role in episodic memory retrieval Learn. Mem., March 1, 2005; 12(2): 193 - 208. [Abstract] [Full Text] [PDF]

				A. Gilboa, G. Winocur, C. L. Grady, S. J. Hevenor, and M. Moscovitch Remembering Our Past: Functional Neuroanatomy of Recollection of Recent and Very Remote Personal Events Cereb Cortex, November 1, 2004; 14(11): 1214 - 1225. [Abstract] [Full Text] [PDF]

				F. Eustache, P. Piolino, B. Giffard, F. Viader, V. D. L. Sayette, J.-C. Baron, and B. Desgranges 'In the course of time': a PET study of the cerebral substrates of autobiographical amnesia in Alzheimer's disease Brain, July 1, 2004; 127(7): 1549 - 1560. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help