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The Journal of Neuroscience, July 2, 2003, 23(13):5634-5644

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Activation of Metabotropic Glutamate 5 and NMDA Receptors Underlies the Induction of Persistent Bursting and Associated Long-Lasting Changes in CA3 Recurrent Connections

Ron Stoop,¹ François Conquet,¹ Benoit Zuber,¹ Leon L. Voronin,² and Etienne Pralong¹

¹Institute of Cellular Biology and Morphology, University of Lausanne, CH-1005 Lausanne, Switzerland, and ²Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117865 Moscow, Russia, and Brain Research Institute, Russian Academy of Medical Sciences, 103064 Moscow, Russia

The aim of this study was to describe the induction and expression mechanisms of a persistent bursting activity in a horizontal slice preparation of the rat limbic system that includes the ventral part of the hippocampus and the entorhinal cortex. Disinhibition of this preparation by bicuculline led to interictal-like bursts in the CA3 region that triggered synchronous activity in the entorhinal cortex. Washout of bicuculline aftera1hr application resulted in a maintained production of hippocampal bursts that continued to spread to the entorhinal cortex. Separation of CA3 from the entorhinal cortex caused the activity in the latter to become asynchronous with CA3 activity in the presence of bicuculline and disappear after washout; however, in CA3, neither the induction of bursting nor its persistence were affected. Associated with the CA3 persistent bursting, a strengthening of recurrent collateral excitatory input to CA3 pyramidal cells and a decreased input to CA3 interneurons was found. Both the induction of the persistent bursting and the changes in synaptic strength were prevented by antagonists of metabotropic glutamate 5 (mGlu5) or NMDA receptors or protein synthesis inhibitors and did not occur in slices from mGlu5 receptor knock-out mice. The above findings suggest potential synaptic mechanisms by which the hippocampus switches to a persistent interictal bursting mode that may support a spread of interictal-like bursting to surrounding temporal lobe regions.

Key words: epilepsy; mGluR5 knockout; interictal bursting; synaptic plasticity; CA3 recurrent collaterals; persistent bursting; horizontal slice

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Received Dec. 9, 2002; revised Apr. 17, 2003; accepted Apr. 21, 2003.

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