WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, July 2, 2003, 23(13):5674-5683

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (90)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McLaughlin, J. P.
Right arrow Articles by Chavkin, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McLaughlin, J. P.
Right arrow Articles by Chavkin, C.

 Previous Article  |  Next Article 

{kappa} Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses

Jay P. McLaughlin, Monica Marton-Popovici, and Charles Chavkin

Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280

Previous studies have demonstrated that stress may increase prodynorphin gene expression, and {kappa} opioid agonists suppress drug reward. Therefore, we tested the hypothesis that stress-induced release of endogenous dynorphin may mediate behavioral responses to stress and oppose the rewarding effects of cocaine. C57Bl/6 mice subjected to repeated forced swim testing (FST) using a modified Porsolt procedure at 30°C showed a characteristic stress-induced immobility response and a stress-induced analgesia observed with a tail withdrawal latency assay. Pretreatment with the {kappa} opioid receptor antagonist nor-binaltorphimine (nor-BNI; 10 mg/kg, i.p.) blocked the stress-induced analgesia and significantly reduced the stress-induced immobility. The nor-BNI sensitivity of the behavioral responses suggests an activation of the {kappa} opioid receptor by a stress-induced release of dynorphin peptides. Supporting this hypothesis, transgenic mice possessing a disrupted prodynorphin gene showed no increase in immobility or stress-induced analgesia after exposure to repeated FST. Because both stress and the {kappa} opioid system can modulate the response to drugs of abuse, we tested the effects of forced swim stress on cocaine-conditioned place preference (CPP). FST-exposed mice conditioned with cocaine (15 mg/kg, s.c.) showed significant potentiation of place preference for the drug-paired chamber over the responses of unstressed mice. Surprisingly, nor-BNI pretreatment blocked stress-induced potentiation of cocaine CPP. Consistent with this result, mice lacking the prodynorphin gene did not show a stress-induced potentiation of cocaine CPP, whereas wild-type littermates did. The findings suggest that chronic swim stress may activate the {kappa} opioid system to produce analgesia, immobility, and potentiation of the acute rewarding properties of cocaine in C57Bl/6 mice.

Key words: {kappa}; opioid; dynorphin; stress; depression; cocaine; conditioned place preference

Received Jan. 27, 2003; revised May. 5, 2003; accepted May. 5, 2003.




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
B. B. Land, M. R. Bruchas, S. Schattauer, W. J. Giardino, M. Aita, D. Messinger, T. S. Hnasko, R. D. Palmiter, and C. Chavkin
Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking
PNAS, November 10, 2009; 106(45): 19168 - 19173.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. V. Aldrich, K. A. Patkar, and J. P. McLaughlin
From the Cover: Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action
PNAS, October 27, 2009; 106(43): 18396 - 18401.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. Le Merrer, J. A. J. Becker, K. Befort, and B. L. Kieffer
Reward Processing by the Opioid System in the Brain
Physiol Rev, October 1, 2009; 89(4): 1379 - 1412.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. M. Navarro, M. L. Gottsch, C. Chavkin, H. Okamura, D. K. Clifton, and R. A. Steiner
Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse
J. Neurosci., September 23, 2009; 29(38): 11859 - 11866.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. N. Carey, A. M. Lyons, C. F. Shay, O. Dunton, and J. P. McLaughlin
Endogenous {kappa} Opioid Activation Mediates Stress-Induced Deficits in Learning and Memory
J. Neurosci., April 1, 2009; 29(13): 4293 - 4300.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
E. H. Chartoff, M. Papadopoulou, M. L. MacDonald, A. Parsegian, D. Potter, C. Konradi, and W. A. Carlezon Jr.
Desipramine Reduces Stress-Activated Dynorphin Expression and CREB Phosphorylation in NAc Tissue
Mol. Pharmacol., March 1, 2009; 75(3): 704 - 712.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Kreibich, B. A. S. Reyes, A. L. Curtis, L. Ecke, C. Chavkin, E. J. V. Bockstaele, and R. J. Valentino
Presynaptic Inhibition of Diverse Afferents to the Locus Ceruleus by {kappa}-Opiate Receptors: A Novel Mechanism for Regulating the Central Norepinephrine System
J. Neurosci., June 18, 2008; 28(25): 6516 - 6525.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. V. Carr and S. D. Mague
p38: The Link between the {kappa}-Opioid Receptor and Dysphoria
J. Neurosci., March 5, 2008; 28(10): 2299 - 2300.
[Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. B. Land, M. R. Bruchas, J. C. Lemos, M. Xu, E. J. Melief, and C. Chavkin
The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin {kappa}-Opioid System
J. Neurosci., January 9, 2008; 28(2): 407 - 414.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
A. T. Knoll, E. G. Meloni, J. B. Thomas, F. I. Carroll, and W. A. Carlezon Jr.
Anxiolytic-Like Effects of {kappa}-Opioid Receptor Antagonists in Models of Unlearned and Learned Fear in Rats
J. Pharmacol. Exp. Ther., December 1, 2007; 323(3): 838 - 845.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. R. Bruchas, B. B. Land, M. Aita, M. Xu, S. K. Barot, S. Li, and C. Chavkin
Stress-Induced p38 Mitogen-Activated Protein Kinase Activation Mediates {kappa}-Opioid-Dependent Dysphoria
J. Neurosci., October 24, 2007; 27(43): 11614 - 11623.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. R. Bruchas, T. Yang, S. Schreiber, M. DeFino, S. C. Kwan, S. Li, and C. Chavkin
Long-Acting {kappa} Opioid Antagonists Disrupt Receptor Signaling And Produce Noncompetitive Effects By Activating C-Jun N-Terminal Kinase
J. Biol. Chem., October 12, 2007; 282(41): 29803 - 29811.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. Li, M. L. Lee, M. R. Bruchas, G. C. Chan, D. R. Storm, and C. Chavkin
Calmodulin-Stimulated Adenylyl Cyclase Gene Deletion Affects Morphine Responses
Mol. Pharmacol., November 1, 2006; 70(5): 1742 - 1749.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. R. Bruchas, T. A. Macey, J. D. Lowe, and C. Chavkin
Kappa Opioid Receptor Activation of p38 MAPK Is GRK3- and Arrestin-dependent in Neurons and Astrocytes
J. Biol. Chem., June 30, 2006; 281(26): 18081 - 18089.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
W. A. Carlezon Jr., C. Beguin, J. A. DiNieri, M. H. Baumann, M. R. Richards, M. S. Todtenkopf, R. B. Rothman, Z. Ma, D. Y.-W. Lee, and B. M. Cohen
Depressive-Like Effects of the {kappa}-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats
J. Pharmacol. Exp. Ther., January 1, 2006; 316(1): 440 - 447.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Xu, M. Petraschka, J. P. McLaughlin, R. E. Westenbroek, M. G. Caron, R. J. Lefkowitz, T. A. Czyzyk, J. E. Pintar, G. W. Terman, and C. Chavkin
Neuropathic Pain Activates the Endogenous {kappa} Opioid System in Mouse Spinal Cord and Induces Opioid Receptor Tolerance
J. Neurosci., May 12, 2004; 24(19): 4576 - 4584.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
C. Chavkin, S. Sud, W. Jin, J. Stewart, J. K. Zjawiony, D. J. Siebert, B. A. Toth, S. J. Hufeisen, and B. L. Roth
Salvinorin A, an Active Component of the Hallucinogenic Sage Salvia divinorum Is a Highly Efficacious {kappa}-Opioid Receptor Agonist: Structural and Functional Considerations
J. Pharmacol. Exp. Ther., March 1, 2004; 308(3): 1197 - 1203.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. de los Santos-Arteaga, S. A. Sierra-Dominguez, G. H. Fontanella, J. M. Delgado-Garcia, and A. M. Carrion
Analgesia Induced by Dietary Restriction Is Mediated by the {kappa}-Opioid System
J. Neurosci., December 3, 2003; 23(35): 11120 - 11126.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-