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The Journal of Neuroscience, July 16, 2003, 23(15):6357-6361

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BRIEF COMMUNICATION
Fast Inhibition Underlies the Transmission of Auditory Information between Cochlear Nuclei

Karina Needham¹ and Antonio G. Paolini^2,3

¹Department of Otolaryngology, The University of Melbourne, East Melbourne, Victoria 3002, Australia, ²The Bionic Ear Institute, East Melbourne, Victoria 3002, Australia, and ³School of Psychological Science, La Trobe University, Bundoora, Victoria 3086, Australia

A direct commissural connection between cochlear nuclei provides a pathway by which binaural input can influence the processing of acoustic information through the ventral cochlear nucleus. Despite anatomical evidence to suggest the existence of such a pathway, its nature and behavior have not been investigated previously. This in vivo intracellular electrophysiological study provides direct evidence of monosynaptic (mean latency, 1.43 msec), inhibitory commissural input to T stellate cells. This inhibition is fast acting (duration, <10 msec), occurring with little synaptic delay (0.3 msec). Electrical stimulation also revealed the initiation of antidromic responses in the onset chopper population, signifying D stellate neurons as a source of commissural inputs. Activation of the commissural connection was most evident in response to broadband stimuli. These results provide the first compelling evidence of a fast, monosynaptic commissural pathway arising from contralateral D stellate neurons providing broadband inhibitory input to T stellate cells.

Key words: ventral cochlear nucleus; commissural connection; stellate neurons; inhibition; in vivo intracellular electrophysiology; antidromic action potential

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Received Apr. 11, 2003; revised May. 19, 2003; accepted May. 20, 2003.

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