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The Journal of Neuroscience, July 23, 2003, 23(16):6399-6403
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BRIEF COMMUNICATION
Identification of a Pax6-Dependent Epidermal Growth Factor Family Signaling Source at the Lateral Edge of the Embryonic Cerebral Cortex
Stavroula Assimacopoulos,
Elizabeth A. Grove, and
Clifton W. Ragsdale
Department of Neurobiology, Pharmacology, and Physiology, The University
of Chicago, Chicago, Illinois 60637
In an emerging model, area patterning of the mammalian cerebral cortex is
regulated in part by embryonic signaling centers. Two have been identified: an
anterior telencephalic source of fibroblast growth factors and the cortical
hem, a medial structure expressing winglessint (WNT) and bone morphogenetic
proteins. We describe a third signaling source, positioned as a mirror image
of the cortical hem, along the lateral margin of the cortical primordium. The
cortical antihem is identified by gene expression for three epidermal growth
factor (EGF) family members, Tgf , Neuregulin 1, and Neuregulin 3, as
well as two other signaling molecules, Fgf7 and the secreted WNT antagonist
Sfrp2. We find that the antihem is lost in mice homozygous for the Small
eye (Pax6) mutation and suggest the loss of EGF signaling at
least partially explains defects in cortical patterning and cell migration in
Small eye mice.
Key words: cortical patterning; Tgf; Neuregulin; Sfrp2; Fgf7; Small eye; Pax6; Emx2
Received Dec. 12, 2002;
revised May. 7, 2003;
accepted May. 16, 2003.
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