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The Journal of Neuroscience, August 13, 2003, 23(19):7343-7350

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Spontaneous Activity of Morphologically Identified Ganglion Cells in the Developing Ferret Retina

Lauren C. Liets,¹ Bruno A. Olshausen,^1,2 Guo-Yong Wang,¹ and Leo M. Chalupa^1,3

¹Section of Neurobiology, Physiology and Behavior, Division of Biological Sciences, ²Center for Neuroscience, and ³Department of Ophthalmology, School of Medicine, University of California, Davis, California 95616

Whole-cell patch-clamp recordings were made from morphologically identified ganglion cells in the intact retina of developing ferrets. As early as 3 d after birth, all ganglion cells exhibited bursts of spontaneous activity, with the interval between bursts gradually decreasing with maturity. By 2 weeks after birth, ganglion cells could be morphologically differentiated into three major classes (, , and ), and at this time each cell class was characterized by a distinct pattern of spontaneous activity. Dual patch-clamp recordings from pairs of neighboring cells revealed that cells of all morphological classes burst in a coordinated manner, regardless of cell type. These observations suggest that a common mechanism underlies the bursting patterns exhibited by all ganglion cell classes, and that class-specific firing patterns emerge coincident with retinal ganglion cell morphological differentiation.

Key words: ganglion cells; retina; spontaneous activity; synchronous activity; retinal development; dual patch-clamp

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Received Mar. 10, 2003; revised May. 1, 2003; accepted Jun. 6, 2003.

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