WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, August 13, 2003, 23(19):7351-7357

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (22)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhao, S.
Right arrow Articles by Frotscher, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhao, S.
Right arrow Articles by Frotscher, M.

 Previous Article  |  Next Article 

Different Signals Control Laminar Specificity of Commissural and Entorhinal Fibers to the Dentate Gyrus

Shanting Zhao, * Eckart Förster, * Xuejun Chai, and Michael Frotscher

Institute of Anatomy, University of Freiburg, D-79001 Freiburg, Germany

The factors governing the characteristic laminated termination of hippocampal afferents are essentially unknown. Principally, diffusible factors of the target region, membrane-bound molecules on the ingrowing afferent fibers and on the postsynaptic target cells as well as molecules of the extracellular matrix (ECM), may play a role. Using slice cocultures as a model, we show that hyaluronic acid, an ECM molecule, is essential for the segregated, layer-specific termination of entorhinal fibers but not of commissural afferents to the mouse dentate gyrus. Laminar specificity of the latter, in contrast, is determined by the position of the postsynaptic granule cells. Thus, malpositioning of the granule cells in slice cultures from reeler mutant mice altered the projection of commissural fibers from cocultured wild-type hippocampus. In contrast, commissural fibers from reeler mouse hippocampus formed a normal, sharply delineated projection to the inner molecular layer of cocultured wild-type dentate gyrus, precluding a cell-autonomous effect of the reeler mutation on commissural neurons. Interestingly enough, entorhinal fibers formed their normal, sharply delineated projection in cocultured reeler dentate gyrus despite the malpositioning of the target granule cells. Because hyaluronan-associated molecules are likely to control the segregated termination of entorhinal fibers, we compared immunolabeling for neurocan and chondroitin sulfate in sections from reeler and wild-type mice and found it similar in both genotypes. Together these results show that different mechanisms underlie the formation of commissural and entorhinal fiber layers during the development of the dentate gyrus.

Key words: hyaluronic acid; chondroitin sulfate proteoglycans; extracellular matrix; reeler mutant; axonal guidance; layer specificity; dentate gyrus

Received Jan. 13, 2003; revised Jun. 9, 2003; accepted Jun. 11, 2003.




This article has been cited by other articles:


Home page
 Cereb CortexHome page
J. Kowalski, M. Geuting, S. Paul, S. Dieni, J. Laurens, S. Zhao, A. Drakew, C. A. Haas, M. Frotscher, and I. Vida
Proper Layering Is Important for Precisely Timed Activation of Hippocampal Mossy Cells
Cereb Cortex, February 1, 2010; (2010): bhp267v2 - bhp267.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Ohshima, T. Kubo, R. Koyama, M. Ueno, M. Nakagawa, and T. Yamashita
Regulation of Axonal Elongation and Pathfinding from the Entorhinal Cortex to the Dentate Gyrus in the Hippocampus by the Chemokine Stromal Cell-Derived Factor 1{alpha}
J. Neurosci., August 13, 2008; 28(33): 8344 - 8353.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Uemura, S. Kakizawa, M. Yamasaki, K. Sakimura, M. Watanabe, M. Iino, and M. Mishina
Regulation of Long-Term Depression and Climbing Fiber Territory by Glutamate Receptor {delta}2 at Parallel Fiber Synapses through its C-Terminal Domain in Cerebellar Purkinje Cells
J. Neurosci., October 31, 2007; 27(44): 12096 - 12108.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Chen, R. A. Bender, K. L. Brunson, J. K. Pomper, D. E. Grigoriadis, W. Wurst, and T. Z. Baram
Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus
PNAS, November 2, 2004; 101(44): 15782 - 15787.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Zhao, X. Chai, E. Forster, and M. Frotscher
Reelin is a positional signal for the lamination of dentate granule cells
Development, October 15, 2004; 131(20): 5117 - 5125.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Brinks, S. Conrad, J. Vogt, J. Oldekamp, A. Sierra, L. Deitinghoff, I. Bechmann, G. Alvarez-Bolado, B. Heimrich, P. P. Monnier, et al.
The Repulsive Guidance Molecule RGMa Is Involved in the Formation of Afferent Connections in the Dentate Gyrus
J. Neurosci., April 14, 2004; 24(15): 3862 - 3869.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2010 by Society for Neuroscience ONLINE ISSN: 1529-2401
-