WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience behavioral testing systems
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, August 13, 2003, 23(19):7368-7375

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (29)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seeds, N. W.
Right arrow Articles by Ferguson, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seeds, N. W.
Right arrow Articles by Ferguson, J. E.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Substance via MeSH

 Previous Article  |  Next Article 

Absence of Tissue Plasminogen Activator Gene or Activity Impairs Mouse Cerebellar Motor Learning

Nicholas W. Seeds, Mark E. Basham, and Jayne E. Ferguson

Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, Colorado 80262

Motor learning is thought to involve modulation of synaptic inputs in the cerebellar cortex, including granule neuron/Purkinje neuron contacts. During a complex motor task requiring mice to walk across irregularly spaced pegs, cerebellar granule neurons show a rapid and transient induction of mRNA for the extracellular protease tissue plasminogen activator (tPA). This induction of tPA mRNA is cerebellar specific, is not seen in the cerebella of exercised or stressed animals, and is distinct from simple performance phenomena. Knock-out mice lacking the tPA gene show a significant reduction in both rate and extent of learning. Furthermore, blocking tPA activity during training dramatically impaired motor learning. Thus, tPA plays an important role in motor learning, in which tPA may facilitate remodeling of the active synaptic zone.

Key words: tPA mRNA; protease inhibitor; PAI-1; granule neuron; synaptic plasticity; memory

Received Apr. 3, 2003; revised Jun. 5, 2003; accepted Jun. 17, 2003.




This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
X. Zhang, R. Polavarapu, H. She, Z. Mao, and M. Yepes
Tissue-Type Plasminogen Activator and the Low-Density Lipoprotein Receptor-Related Protein Mediate Cerebral Ischemia-Induced Nuclear Factor-{kappa}B Pathway Activation
Am. J. Pathol., October 1, 2007; 171(4): 1281 - 1290.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
K. Benchenane, H. Castel, M. Boulouard, R. Bluthe, M. Fernandez-Monreal, B. D. Roussel, J. P. Lopez-Atalaya, S. Butt-Gueulle, V. Agin, E. Maubert, et al.
Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memory
J. Cell Sci., February 15, 2007; 120(4): 578 - 585.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. A. Miles, N. M. Andronicos, N. Baik, and R. J. Parmer
Cell-Surface Actin Binds Plasminogen and Modulates Neurotransmitter Release from Catecholaminergic Cells
J. Neurosci., December 13, 2006; 26(50): 13017 - 13024.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Li, J. Imitola, E. Y. Snyder, and R. L. Sidman
Neural stem cells rescue nervous purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets.
J. Neurosci., July 26, 2006; 26(30): 7839 - 7848.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Li, Y. Ma, Y. D. Teng, K. Zheng, T. K. Vartanian, E. Y. Snyder, and R. L. Sidman
Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator
PNAS, May 16, 2006; 103(20): 7847 - 7852.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Fernandez-Monreal, J. P. Lopez-Atalaya, K. Benchenane, M. Cacquevel, F. Dulin, J.-P. Le Caer, J. Rossier, A.-C. Jarrige, E. T. MacKenzie, N. Colloc'h, et al.
Arginine 260 of the Amino-terminal Domain of NR1 Subunit Is Critical for Tissue-type Plasminogen Activator-mediated Enhancement of N-Methyl-D-aspartate Receptor Signaling
J. Biol. Chem., December 3, 2004; 279(49): 50850 - 50856.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
M. Yepes and D. A. Lawrence
New Functions for an Old Enzyme: Nonhemostatic Roles for Tissue-Type Plasminogen Activator in the Central Nervous System
Experimental Biology and Medicine, December 1, 2004; 229(11): 1097 - 1104.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Kvajo, H. Albrecht, M. Meins, U. Hengst, E. Troncoso, S. Lefort, J. Z. Kiss, C. C. H. Petersen, and D. Monard
Regulation of Brain Proteolytic Activity Is Necessary for the In Vivo Function of NMDA Receptors
J. Neurosci., October 27, 2004; 24(43): 9734 - 9743.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Y. Shin, M. Kundel, and D. G. Wells
Rapid, Activity-Induced Increase in Tissue Plasminogen Activator Is Mediated by Metabotropic Glutamate Receptor-Dependent mRNA Translation
J. Neurosci., October 20, 2004; 24(42): 9425 - 9433.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-