 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, January 15, 2003, 23(2):530-538
The L1 Cell Adhesion Molecule Is Essential for Topographic Mapping of Retinal Axons
Galina P. Demyanenko and Patricia F. Maness Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7260
The retinocollicular projection is a preferred axon guidance pathway for investigating molecular mechanisms of synaptic targeting in the mammalian CNS. Here we identify a previously unrecognized role of the L1 cell adhesion molecule in topographic mapping of retinal ganglion cell (RGC) axons to their targets in the mouse superior colliculus (SC). L1 was transiently expressed on RGC axons during axon growth and targeting. DiI labeling of retinal axons revealed that temporal axons of L1-minus mice bypassed correct target locations in the anterior SC, forming termination zones at incorrect posterior sites, which were often skewed along the mediolateral axis. During development of the retinotopic map L1-minus temporal axons extended across the anteroposterior axis of the SC like wild-type axons but failed to arborize at normal anterior target sites. L1-minus RGC axons exhibited normal crossing at the optic chiasm and fasciculation of the optic nerve. Results suggest that retinal axons require the function of L1 in addition to repellent EphA guidance receptors to achieve proper topographic mapping.
Key words: L1; cell adhesion molecule; axon guidance; retinocollicular mapping; synaptic targeting; ephrin
Copyright © 2003 Society for Neuroscience 0270-6474/03/232530-09$05.00/0
This article has been cited by other articles:
E. Chatzopoulou, A. Miguez, M. Savvaki, G. Levasseur, A. Muzerelle, M.-P. Muriel, O. Goureau, K. Watanabe, L. Goutebroze, P. Gaspar, et al.
Structural Requirement of TAG-1 for Retinal Ganglion Cell Axons and Myelin in the Mouse Optic Nerve
J. Neurosci., July 23, 2008; 28(30): 7624 - 7636.
[Abstract] [Full Text] [PDF]
L. Pan, M. Deng, X. Xie, and L. Gan
ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells
Development, June 1, 2008; 135(11): 1981 - 1990.
[Abstract] [Full Text] [PDF]
M. Buhusi, M. C. Schlatter, G. P. Demyanenko, R. Thresher, and P. F. Maness
L1 Interaction with Ankyrin Regulates Mediolateral Topography in the Retinocollicular Projection
J. Neurosci., January 2, 2008; 28(1): 177 - 188.
[Abstract] [Full Text] [PDF]
Y. Chen, C. L. Hehr, K. Atkinson-Leadbeater, J. C. Hocking, and S. McFarlane
Targeting of Retinal Axons Requires the Metalloproteinase ADAM10
J. Neurosci., August 1, 2007; 27(31): 8448 - 8456.
[Abstract] [Full Text] [PDF]
T. Harada, C. Harada, and L. F. Parada
Molecular regulation of visual system development: more than meets the eye
Genes & Dev., February 15, 2007; 21(4): 367 - 378.
[Abstract] [Full Text] [PDF]
T. Xiao, T. Roeser, W. Staub, and H. Baier
A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection
Development, July 1, 2005; 132(13): 2955 - 2967.
[Abstract] [Full Text] [PDF]
L. Pan, Z. Yang, L. Feng, and L. Gan
Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesis
Development, February 15, 2005; 132(4): 703 - 712.
[Abstract] [Full Text] [PDF]
Y. Sara, T. Biederer, D. Atasoy, A. Chubykin, M. G. Mozhayeva, T. C. Sudhof, and E. T. Kavalali
Selective Capability of SynCAM and Neuroligin for Functional Synapse Assembly
J. Neurosci., January 5, 2005; 25(1): 260 - 270.
[Abstract] [Full Text] [PDF]
F. de Winter, Q. Cui, N. Symons, J. Verhaagen, and A. R. Harvey
Expression of Class-3 Semaphorins and Their Receptors in the Neonatal and Adult Rat Retina
Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4554 - 4562.
[Abstract] [Full Text] [PDF]
A.E. Wiencken-Barger, J. Mavity-Hudson, U. Bartsch, M. Schachner, and V.A. Casagrande
The Role of L1 in Axon Pathfinding and Fasciculation
Cereb Cortex, February 1, 2004; 14(2): 121 - 131.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|