QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, August 20, 2003, 23(20):7630-7641

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (26) Citing Articles via Google Scholar Google Scholar Articles by Averbeck, B. B. Articles by Lee, D. Search for Related Content PubMed PubMed Citation Articles by Averbeck, B. B. Articles by Lee, D.

 Previous Article  |  Next Article 

Neural Noise and Movement-Related Codes in the Macaque Supplementary Motor Area

Bruno B. Averbeck and Daeyeol Lee

Department of Brain and Cognitive Sciences and Center for Visual Science, University of Rochester, Rochester, New York 14627

We analyzed the variability of spike counts and the coding capacity of simultaneously recorded pairs of neurons in the macaque supplementary motor area (SMA). We analyzed the mean-variance functions for single neurons, as well as signal and noise correlations between pairs of neurons. All three statistics showed a strong dependence on the bin width chosen for analysis. Changes in the correlation structure of single neuron spike trains over different bin sizes affected the mean-variance function, and signal and noise correlations between pairs of neurons were much smaller at small bin widths, increasing monotonically with the width of the bin. Analyses in the frequency domain showed that the noise between pairs of neurons, on average, was most strongly correlated at low frequencies, which explained the increase in noise correlation with increasing bin width.

The coding performance was analyzed to determine whether the temporal precision of spike arrival times and the interactions within and between neurons could improve the prediction of the upcoming movement. We found that in 62% of neuron pairs, the arrival times of spikes at a resolution between 66 and 40 msec carried more information than spike counts in a 200 msec bin. In addition, in 19% of neuron pairs, inclusion of within (11%)- or between-neuron (8%) correlations in spike trains improved decoding accuracy. These results suggest that in some SMA neurons elements of the spatiotemporal pattern of activity may be relevant for neural coding.

Key words: spike count variability; correlated noise; monkey; decoding; temporal code; rate code

---

Received May. 20, 2003; revised Jun. 27, 2003; accepted Jul. 7, 2003.

This article has been cited by other articles:

				N. S. Narayanan and M. Laubach Delay Activity in Rodent Frontal Cortex During a Simple Reaction Time Task J Neurophysiol, June 1, 2009; 101(6): 2859 - 2871. [Abstract] [Full Text] [PDF]

				M. R. Cohen and W. T. Newsome Estimates of the Contribution of Single Neurons to Perception Depend on Timescale and Noise Correlation J. Neurosci., May 20, 2009; 29(20): 6635 - 6648. [Abstract] [Full Text] [PDF]

				A. L. Jacobs, G. Fridman, R. M. Douglas, N. M. Alam, Peter. E. Latham, G. T. Prusky, and S. Nirenberg Ruling out and ruling in neural codes PNAS, April 7, 2009; 106(14): 5936 - 5941. [Abstract] [Full Text] [PDF]

				L. C. Osborne, S. E. Palmer, S. G. Lisberger, and W. Bialek The Neural Basis for Combinatorial Coding in a Cortical Population Response J. Neurosci., December 10, 2008; 28(50): 13522 - 13531. [Abstract] [Full Text] [PDF]

				S. B. Hamed, M. H. Schieber, and A. Pouget Decoding M1 Neurons During Multiple Finger Movements J Neurophysiol, July 1, 2007; 98(1): 327 - 333. [Abstract] [Full Text] [PDF]

				F. Montani, A. Kohn, M. A. Smith, and S. R. Schultz The Role of Correlations in Direction and Contrast Coding in the Primary Visual Cortex J. Neurosci., February 28, 2007; 27(9): 2338 - 2348. [Abstract] [Full Text] [PDF]

				B. B. Averbeck and D. Lee Effects of Noise Correlations on Information Encoding and Decoding J Neurophysiol, June 1, 2006; 95(6): 3633 - 3644. [Abstract] [Full Text] [PDF]

				M. M. Churchland, B. M. Yu, S. I. Ryu, G. Santhanam, and K. V. Shenoy Neural variability in premotor cortex provides a signature of motor preparation. J. Neurosci., April 5, 2006; 26(14): 3697 - 3712. [Abstract] [Full Text] [PDF]

				T. Vladusich, M. P. Lucassen, and F. W. Cornelissen Do Cortical Neurons Process Luminance or Contrast to Encode Surface Properties? J Neurophysiol, April 1, 2006; 95(4): 2638 - 2649. [Abstract] [Full Text] [PDF]

				P. E. Latham and S. Nirenberg Synergy, Redundancy, and Independence in Population Codes, Revisited J. Neurosci., May 25, 2005; 25(21): 5195 - 5206. [Abstract] [Full Text] [PDF]

				A. Kohn and M. A. Smith Stimulus Dependence of Neuronal Correlation in Primary Visual Cortex of the Macaque J. Neurosci., April 6, 2005; 25(14): 3661 - 3673. [Abstract] [Full Text] [PDF]

				A. Mazzoni, E. Garcia-Perez, D. Zoccolan, S. Graziosi, and V. Torre Quantitative Characterization and Classification of Leech Behavior J Neurophysiol, January 1, 2005; 93(1): 580 - 593. [Abstract] [Full Text] [PDF]

				D. Cohen and M. A. L. Nicolelis Reduction of Single-Neuron Firing Uncertainty by Cortical Ensembles during Motor Skill Learning J. Neurosci., April 7, 2004; 24(14): 3574 - 3582. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help