 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, September 3, 2003, 23(22):8002-8012
Previous Article | Next Article
Neural Coding of "Attention for Action" and "Response Selection" in Primate Anterior Cingulate Cortex
Yoshikazu Isomura,1,2,3 Yumi Ito,1 Toshikazu Akazawa,1 Atsushi Nambu,1,2 andMasahiko Takada1,2 1Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183-8526, Japan, 2 Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Kawaguchi, Saitama 332-0012, Japan, and 3The Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo 102-8471, Japan
Noninvasive imaging techniques showed that the anterior cingulate cortex is related to higher-order cognitive and motor-related functions in humans. To elucidate the cellular mechanism of such cingulate functions, single-unit activity was recorded from three cingulate motor areas of macaque monkeys performing delayed conditional Go/No-go discrimination tasks using spatial (location) and nonspatial (color) visual cues. Unlike prefrontal neurons, only a few neurons coded the visual information on individual features (e.g., "left" or "red") in all of the rostral (CMAr), dorsal (CMAd), and ventral (CMAv) cingulate motor areas. Instead, many neurons in the CMAr exhibited the attention-like activity anticipating the second (conditioned) visual cues, with the specificity to visual category ("location" or "color"). In addition, there were a number of CMAr neurons specific to motor response (Go or No-go) in relation to the second visual cues. Some of the visual category-specific neurons in the CMAr further displayed the motor response-specific activity. On the other hand, many of the task-related CMAd and CMAv neurons seemed to be implicated directly in motor functions, such as preparation and execution of movements in Go trials. The present results suggest that the CMAr neurons may participate in cognitive and motor functions of "attention for action" and "response selection" for an appropriate action according to an intention, whereas the CMAd and CMAv neurons may be involved in "motor preparation and execution".
Key words: Go/No-go discrimination; anterior attention system; motor decision; cingulate motor areas; single-unit recording; macaque monkey
Received Feb 25, 2003; revised June 23, 2003; accepted July 9, 2003.
This article has been cited by other articles:
R. P. Dum, D. J. Levinthal, and P. L. Strick
The Spinothalamic System Targets Motor and Sensory Areas in the Cerebral Cortex of Monkeys
J. Neurosci., November 11, 2009; 29(45): 14223 - 14235.
[Abstract] [Full Text] [PDF]
N. Hatanaka, H. Tokuno, A. Nambu, and M. Takada
Transdural Doppler Ultrasonography Monitors Cerebral Blood Flow Changes in Relation to Motor Tasks
Cereb Cortex, April 1, 2009; 19(4): 820 - 831.
[Abstract] [Full Text] [PDF]
C. B. Holroyd, O. E. Krigolson, R. Baker, S. Lee, and J. Gibson
When is an error not a prediction error? An electrophysiological investigation
Cogn Affect Behav Neurosci, March 1, 2009; 9(1): 59 - 70.
[Abstract] [PDF]
C. C. Lapish, D. Durstewitz, L. J. Chandler, and J. K. Seamans
Successful choice behavior is associated with distinct and coherent network states in anterior cingulate cortex
PNAS, August 19, 2008; 105(33): 11963 - 11968.
[Abstract] [Full Text] [PDF]
J. Fan, P. R. Hof, K. G. Guise, J. A. Fossella, and M. I. Posner
The Functional Integration of the Anterior Cingulate Cortex during Conflict Processing
Cereb Cortex, April 1, 2008; 18(4): 796 - 805.
[Abstract] [Full Text] [PDF]
E. E. Emeric, J. W. Brown, M. Leslie, P. Pouget, V. Stuphorn, and J. D. Schall
Performance Monitoring Local Field Potentials in the Medial Frontal Cortex of Primates: Anterior Cingulate Cortex
J Neurophysiol, February 1, 2008; 99(2): 759 - 772.
[Abstract] [Full Text] [PDF]
T. Michelet, B. Bioulac, D. Guehl, L. Escola, and P. Burbaud
Impact of Commitment on Performance Evaluation in the Rostral Cingulate Motor Area
J. Neurosci., July 11, 2007; 27(28): 7482 - 7489.
[Abstract] [Full Text] [PDF]
H. Okamoto, Y. Isomura, M. Takada, and T. Fukai
Temporal Integration by Stochastic Recurrent Network Dynamics With Bimodal Neurons
J Neurophysiol, June 1, 2007; 97(6): 3859 - 3867.
[Abstract] [Full Text] [PDF]
J. Fan, R. Kolster, J. Ghajar, M. Suh, R. T. Knight, R. Sarkar, and B. D. McCandliss
Response Anticipation and Response Conflict: An Event-Related Potential and Functional Magnetic Resonance Imaging Study
J. Neurosci., February 28, 2007; 27(9): 2272 - 2282.
[Abstract] [Full Text] [PDF]
A. Genovesio, S. Tsujimoto, and S. P. Wise
Neuronal Activity Related to Elapsed Time in Prefrontal Cortex
J Neurophysiol, May 1, 2006; 95(5): 3281 - 3285.
[Abstract] [Full Text] [PDF]
P. Pouget, E. E. Emeric, V. Stuphorn, K. Reis, and J. D. Schall
Chronometry of Visual Responses in Frontal Eye Field, Supplementary Eye Field, and Anterior Cingulate Cortex
J Neurophysiol, September 1, 2005; 94(3): 2086 - 2092.
[Abstract] [Full Text] [PDF]
E. Hoshi, H. Sawamura, and J. Tanji
Neurons in the Rostral Cingulate Motor Area Monitor Multiple Phases of Visuomotor Behavior With Modest Parametric Selectivity
J Neurophysiol, July 1, 2005; 94(1): 640 - 656.
[Abstract] [Full Text] [PDF]
S. Miyachi, X. Lu, S. Inoue, T. Iwasaki, S. Koike, A. Nambu, and M. Takada
Organization of Multisynaptic Inputs from Prefrontal Cortex to Primary Motor Cortex as Revealed by Retrograde Transneuronal Transport of Rabies Virus
J. Neurosci., March 9, 2005; 25(10): 2547 - 2556.
[Abstract] [Full Text] [PDF]
K. E. Macey, P. M. Macey, M. A. Woo, R. K. Harper, J. R. Alger, T. G. Keens, and R. M. Harper
fMRI signal changes in response to forced expiratory loading in congenital central hypoventilation syndrome
J Appl Physiol, November 1, 2004; 97(5): 1897 - 1907.
[Abstract] [Full Text] [PDF]
C. Francois, D. Grabli, K. McCairn, C. Jan, C. Karachi, E.-C. Hirsch, J. Feger, and L. Tremblay
Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical study
Brain, September 1, 2004; 127(9): 2055 - 2070.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|