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The Journal of Neuroscience, September 10, 2003, 23(23):8380-8391

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The Origin of Cortical Surround Receptive Fields Studied in the Barrel Cortex

Kevin Fox, Nicholas Wright, Helen Wallace, and Stanislaw Glazewski

School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom

The neocortex is thought to be organized into functional columns of neurons, each of which processes an element of a larger representation. In the barrel cortex, the thalamic input to the column preferentially terminates in a barrel. To study the extent and nature of functional connections between columns, we measured the degree to which whisker responses are relayed between columns in the barrel cortex. Inactivating a single barrel by iontophoresis of the GABA_A agonist muscimol abolished the representation of that barrel's whisker in neighboring barrels. Reactivating a single barrel by iontophoresis of the GABA_A antagonist bicuculline while the rest of the cortex was blocked by muscimol led to single whisker receptive fields. Under the same conditions, septal cells tended to exhibit multiwhisker receptive fields. These studies demonstrate that the surround receptive fields of barrel cells are generated by intracortical transmission and that many septal cells derive a component of their surround receptive field from the thalamus.

Key words: barrels; whiskers; GABA; rat; sensory processing; muscimol

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Received Feb 20, 2003; revised June 10, 2003; accepted June 18, 2003.

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