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The Journal of Neuroscience, September 24, 2003, 23(25):8630-8640

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Behavioral/Systems/Cognitive
Development of the Spatial Organization and Dynamics of Lateral Interactions in the Human Visual System

Chuan Hou,¹ Mark W. Pettet,¹ Vanitha Sampath,¹ T. Rowan Candy,² and Anthony M. Norcia¹

¹The Smith-Kettlewell Eye Research Institute, San Francisco, California 94115, and ²School of Optometry, Indiana University, Bloomington, Indiana 47405

Psychophysical thresholds and neuronal responses for isolated stimuli are strongly modified by nearby stimuli in the visual field. We studied the orientation and position specificity of these contextual interactions using a dual-frequency visual-evoked potential technique in developing human infants and adults. One set of small, oriented stimulus elements (targets) was tagged with a temporal frequency f₁ of 4.52 Hz. The addition of an abutting second set of similar patches (flankers) tagged at f₂ = 2.58 Hz had three effects: (1) The flankers reduced the second and fourth harmonic responses to the targets. This reduction was independent of flanker orientation or position and age. (2) The response to the combination of targets and flankers also contained nonlinear interaction terms (1f₁ ± 1f₂) that were tuned for flanker orientation and position in adults, but only for flanker orientation in infants 8-31 weeks of age. (3) Nonlinear interaction terms recorded at 2f₁ ± 2f₂ were large and untuned for flanker orientation and position in adults but were nearly absent in the youngest infants. The three forms of nonlinear interaction, thus, have differences in sensitivity to flanker orientation and position and differential growth trends, indicating that they are generated by different mechanisms. These three forms of interaction could serve different functional roles. The first process provides a nonselective gain control that is fully functional in early infancy. The second process, which develops slowly, is selective for the specific form of the stimuli. The third process, which is also immature, pools across orientation.

Key words: suppression; masking; lateral interaction; cortex; orientation; configuration

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Received Feb 20, 2003; revised June 26, 2003; accepted July 8, 2003.

This article has been cited by other articles:

				B. Zhang, J. Zheng, I. Watanabe, I. Maruko, H. Bi, E. L. Smith III, and Y. Chino Delayed maturation of receptive field center/surround mechanisms in V2 PNAS, April 19, 2005; 102(16): 5862 - 5867. [Abstract] [Full Text] [PDF]

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