WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, September 24, 2003, 23(25):8649-8663

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (26)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mickey, B. J.
Right arrow Articles by Middlebrooks, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mickey, B. J.
Right arrow Articles by Middlebrooks, J. C.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Representation of Auditory Space by Cortical Neurons in Awake Cats

Brian J. Mickey and John C. Middlebrooks

Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109-0506

We evaluated the spatial selectivity of auditory cortical neurons in awake cats. Single- and multiunit activity was recorded in primary auditory cortex as the animals performed a nonspatial auditory discrimination or sat idly. Their heads were unrestrained, and head position was tracked. Broadband sounds were delivered from locations throughout 360° on the horizontal plane, and source locations were expressed in head-centered coordinates. As in anesthetized animals, the firing rates of most units were modulated by sound location, and most units responded best to sounds in the contralateral hemifield. Tuning was sharper than in anesthetized cats, in part because of suppression at nonoptimal locations. Nonetheless, spatial receptive fields typically spanned 150-180°. Units exhibited diverse temporal response patterns that often depended on sound location. An information-theoretic analysis showed that information transmission was reduced by ~10% when the precision of spike timing was disrupted by 16-32 msec, and by ~50% when all location-related variation of spike timing was removed. Spikes occurring within 60 msec of stimulus onset transmitted the most location-related information, but later spikes also carried information. The amount of information transmitted by ensembles of units increased with the number of units, indicating some degree of mutual independence in the spatial information transmitted by various units. Spatial tuning and information transmission were changed little by an increase in sound level of 20-30 dB. For the vast majority of units, receptive fields showed no significant change with the cat's head position or level of participation in the auditory task.

Key words: sound localization; spatial hearing; auditory cortex; unanesthetized; space perception; level invariance; spike timing

Received June 21, 2003; revised July 24, 2003; accepted July 27, 2003.




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
L. M. Miller and G. H. Recanzone
Populations of auditory cortical neurons can accurately encode acoustic space across stimulus intensity
PNAS, April 7, 2009; 106(14): 5931 - 5935.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. H. Scott, B. J. Malone, and M. N. Semple
Representation of Dynamic Interaural Phase Difference in Auditory Cortex of Awake Rhesus Macaques
J Neurophysiol, April 1, 2009; 101(4): 1781 - 1799.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Huetz, B. Philibert, and J.-M. Edeline
A Spike-Timing Code for Discriminating Conspecific Vocalizations in the Thalamocortical System of Anesthetized and Awake Guinea Pigs
J. Neurosci., January 14, 2009; 29(2): 334 - 350.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. C. Middlebrooks
Auditory Cortex Phase Locking to Amplitude-Modulated Cochlear Implant Pulse Trains
J Neurophysiol, July 1, 2008; 100(1): 76 - 91.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Las, A.-H. Shapira, and I. Nelken
Functional Gradients of Auditory Sensitivity along the Anterior Ectosylvian Sulcus of the Cat
J. Neurosci., April 2, 2008; 28(14): 3657 - 3667.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
U. Werner-Reiss and J. M. Groh
A Rate Code for Sound Azimuth in Monkey Auditory Cortex: Implications for Human Neuroimaging Studies
J. Neurosci., April 2, 2008; 28(14): 3747 - 3758.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Ter-Mikaelian, D. H. Sanes, and M. N. Semple
Transformation of Temporal Properties between Auditory Midbrain and Cortex in the Awake Mongolian Gerbil
J. Neurosci., June 6, 2007; 27(23): 6091 - 6102.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. M. Woods, S. E. Lopez, J. H. Long, J. E. Rahman, and G. H. Recanzone
Effects of Stimulus Azimuth and Intensity on the Single-Neuron Activity in the Auditory Cortex of the Alert Macaque Monkey
J Neurophysiol, December 1, 2006; 96(6): 3323 - 3337.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Moshitch, L. Las, N. Ulanovsky, O. Bar-Yosef, and I. Nelken
Responses of Neurons in Primary Auditory Cortex (A1) to Pure Tones in the Halothane-Anesthetized Cat
J Neurophysiol, June 1, 2006; 95(6): 3756 - 3769.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. C. Schadt, H. L. Shafford, and M. D. McKown
Neuronal activity within the ventrolateral periaqueductal gray during simulated hemorrhage in conscious rabbits
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R715 - R725.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. J. Mickey and J. C. Middlebrooks
Sensitivity of Auditory Cortical Neurons to the Locations of Leading and Lagging Sounds
J Neurophysiol, August 1, 2005; 94(2): 979 - 989.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. C. Stecker, I. A. Harrington, E. A. Macpherson, and J. C. Middlebrooks
Spatial Sensitivity in the Dorsal Zone (Area DZ) of Cat Auditory Cortex
J Neurophysiol, August 1, 2005; 94(2): 1267 - 1280.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. B. Merriam, T. I. Netoff, and M. I. Banks
Bistable Network Behavior of Layer I Interneurons in Auditory Cortex
J. Neurosci., June 29, 2005; 25(26): 6175 - 6186.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. D. Mrsic-Flogel, A. J. King, and J. W. H. Schnupp
Encoding of Virtual Acoustic Space Stimuli by Neurons in Ferret Primary Auditory Cortex
J Neurophysiol, June 1, 2005; 93(6): 3489 - 3503.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Arabzadeh, S. Panzeri, and M. E. Diamond
Whisker Vibration Information Carried by Rat Barrel Cortex Neurons
J. Neurosci., June 30, 2004; 24(26): 6011 - 6020.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-