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The Journal of Neuroscience, September 24, 2003, 23(25):8752-8758
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Cellular/Molecular
A Specific Inhibitory Pathway between Substantia Gelatinosa Neurons Receiving Direct C-Fiber Input
Yan Lu andEdward R. Perl Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599
The spinal substantia gelatinosa (SG) is a major termination region for unmyelinated (C) primary afferent fibers; however, how the input it receives from these sensory fibers is processed by SG neurons remains primarily a matter of conjecture. To gain insight on connections and functional interactions between intrinsic SG neurons, simultaneous tight-seal, whole-cell recordings were made from pairs of neurons in rat spinal cord slices to examine whether impulses in one cell generated synaptic activity in the other. Most SG neuron pairs sampled lacked synaptic interaction. Those showing a linkage included a recurring pattern consisting of a monosynaptic, bicuculline-sensitive inhibitory connection from an islet cell to a transient central neuron, each of which received direct excitatory input from different afferent C-fibers. This newly defined inhibitory circuit is postulated to represent a SG neural module by which a nociceptive C-fiber input to transient central cells is modified by other C-fiber messages.
Key words: inhibitory pathway; substantia gelatinosa; spinal lamina II; afferent C-fibers; islet neurons; GABAA; nociception
Received June 10, 2003; revised July 31, 2003; accepted August 1, 2003.
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