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The Journal of Neuroscience, October 1, 2003, 23(26):8820-8826

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Behavioral/Systems/Cognitive
Calbindin Influences Response to Photic Input in Suprachiasmatic Nucleus

Toshiyuki Hamada,¹ Joseph LeSauter,² Maria Lokshin,¹ Maria-Teresa Romero,³ Lily Yan,¹ Judith M. Venuti,⁴ and Rae Silver^1,2,5

Departments of Psychology, ¹Columbia University and ²Barnard College, New York, New York 10027, ³Department of Psychology, Binghamton University, State University of New York, New York 13902, ⁴Department of Cell Biology and Anatomy, Louisiana State University Medical Center, New Orleans, Louisiana 70112, and ⁵Department of Anatomy and Cell Biology, Columbia University, New York, New York 10027

It is well known that light resets the circadian clock only at specific times of day. The mechanisms mediating such gating of environmental input to the CNS are not well understood. We show that calbindin_D28K (CalB)-containing cells of the suprachiasmatic nucleus (SCN), which are directly retinorecipient, gate photic entrainment of cellular circadian oscillators and thereby determine the timing of locomotor rhythmicity. Specifically, we demonstrate a circadian rhythm of subcellular localization of CalB: whereas the protein is detected at all times in the cytoplasm, it is low or absent in the nucleus during the night. Under normal circumstances, light-induced behavioral phase shifts and Period (Per) gene expression in the SCN occur only during the subjective night. Surprisingly, both behavioral phase shifts and light-induced Per are blocked during the subjective night and enhanced during the subjective day after administration of CalB antisense oligodeoxynucleotides. These results suggest a cellular basis for temporal gating of photic input to the circadian clock.

Key words: suprachiasmatic nucleus; calbindin_D28K; Per1; vasopressin; digoxigenin in situ hybridization; locomotor activity rhythm

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Received June 9, 2003; revised August 1, 2003; accepted August 6, 2003.

This article has been cited by other articles:

				J. LeSauter, T. Bhuiyan, T. Shimazoe, and R. Silver Circadian Trafficking of Calbindin-ir in Fibers of SCN Neurons J Biol Rhythms, December 1, 2009; 24(6): 488 - 496. [Abstract] [PDF]

				C. Mercado, M. Diaz-Munoz, J. Alamilla, K. Valderrama, V. Morales-Tlalpan, and R. Aguilar-Roblero Ryanodine-Sensitive Intracellular Ca2+ Channels in Rat Suprachiasmatic Nuclei Are Required for Circadian Clock Control of Behavior J Biol Rhythms, June 1, 2009; 24(3): 203 - 210. [Abstract] [PDF]

				L. P. Morin SCN Organization Reconsidered J Biol Rhythms, February 1, 2007; 22(1): 3 - 13. [Abstract] [PDF]

				L. Yan, I. Karatsoreos, J. LeSauter, D. K. Welsh, S. Kay, D. Foley, and R. Silver Exploring Spatiotemporal Organization of SCN Circuits Cold Spring Harb Symp Quant Biol, January 1, 2007; 72(0): 527 - 541. [Abstract] [PDF]

				M. C. Antle, L. J. Kriegsfeld, and R. Silver Signaling within the Master Clock of the Brain: Localized Activation of Mitogen-Activated Protein Kinase by Gastrin-Releasing Peptide J. Neurosci., March 9, 2005; 25(10): 2447 - 2454. [Abstract] [Full Text] [PDF]

				M. Ikeda Calcium Dynamics and Circadian Rhythms in Suprachiasmatic Nucleus Neurons Neuroscientist, August 1, 2004; 10(4): 315 - 324. [Abstract] [PDF]

				L. J. Kriegsfeld, J. LeSauter, and R. Silver Targeted Microlesions Reveal Novel Organization of the Hamster Suprachiasmatic Nucleus J. Neurosci., March 10, 2004; 24(10): 2449 - 2457. [Abstract] [Full Text] [PDF]

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