QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, October 22, 2003, 23(29):9595-9599

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Rose, J. K. Articles by Rankin, C. H. Search for Related Content PubMed PubMed Citation Articles by Rose, J. K. Articles by Rankin, C. H.

 Previous Article  |  Next Article 

BRIEF COMMUNICATION
GLR-1, a Non-NMDA Glutamate Receptor Homolog, Is Critical for Long-Term Memory in Caenorhabditis elegans

Jacqueline K. Rose, Karla R. Kaun, Sylvia H. Chen, and Catharine H. Rankin

Department of Psychology and Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4

Long-term memory for habituation to tap in Caenorhabditis elegans depends on glr-1, a homolog of mammalian non-NMDA glutamate receptors; mutations in glr-1 blocked long-term memory formation. Green fluorescent protein (GFP) constructs were used to visualize glr-1 expression in the interneurons of the mechanosensory circuit and synaptobrevin in the tap sensory neurons of trained and untrained worms. Trained animals had less GLR-1::GFP expression than untrained animals; there was no difference in the vesicle marker synaptobrevin. Heat shock during training blocked both the behavioral expression of long-term memory and the change in GLR-1::GFP expression. Thus, long-term memory in C. elegans is dependent on glr-1 and likely involves changes in the expression or localization of glutamate receptors.

Key words: C. elegans; habituation; long-term memory; glutamate receptors; synaptobrevin; LTD

---

Received June 25, 2003; revised September 3, 2003; accepted September 3, 2003.

This article has been cited by other articles:

				D. A. Wilson and C. Linster Neurobiology of a Simple Memory J Neurophysiol, July 1, 2008; 100(1): 2 - 7. [Abstract] [Full Text] [PDF]

				D. D. Ikeda, Y. Duan, M. Matsuki, H. Kunitomo, H. Hutter, E. M. Hedgecock, and Y. Iino CASY-1, an ortholog of calsyntenins/alcadeins, is essential for learning in Caenorhabditis elegans PNAS, April 1, 2008; 105(13): 5260 - 5265. [Abstract] [Full Text] [PDF]

				I. Torayama, T. Ishihara, and I. Katsura Caenorhabditis elegans Integrates the Signals of Butanone and Food to Enhance Chemotaxis to Butanone J. Neurosci., January 24, 2007; 27(4): 741 - 750. [Abstract] [Full Text] [PDF]

				J. K. Rose and C. H. Rankin Blocking memory reconsolidation reverses memory-associated changes in glutamate receptor expression. J. Neurosci., November 8, 2006; 26(45): 11582 - 11587. [Abstract] [Full Text] [PDF]

				D. L. Glanzman The Cellular Mechanisms of Learning in Aplysia: Of Blind Men and Elephants Biol. Bull., June 1, 2006; 210(3): 271 - 279. [Abstract] [Full Text] [PDF]

				J. K. Rose, S. Sangha, S. Rai, K. R. Norman, and C. H. Rankin Decreased Sensory Stimulation Reduces Behavioral Responding, Retards Development, and Alters Neuronal Connectivity in Caenorhabditis elegans J. Neurosci., August 3, 2005; 25(31): 7159 - 7168. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help