QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (65) Citing Articles via Google Scholar Google Scholar Articles by Liu, S. Articles by Lu, Y. Search for Related Content PubMed PubMed Citation Articles by Liu, S. Articles by Lu, Y. Pubmed/NCBI databases Compound via MeSH Substance via MeSH

 Previous Article  |  Next Article 

The Journal of Neuroscience, February 1, 2003, 23(3):732

BRIEF COMMUNICATION
Generation of Functional Inhibitory Neurons in the Adult Rat Hippocampus

ShuHong Liu, Jian Wang, DongYa Zhu, YangPing Fu, Ken Lukowiak, and YouMing Lu

Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada, T2N 4N1

Several thousand new neurons are produced each day in the adult mammalian hippocampus, among which only excitatory granule cells (GCs) have thus far been identified. In the present study, we used mutant Semliki Forest Virus vectors to express enhanced green fluorescent protein in the hippocampus, and observed that ~14% of newly generated neurons in the dentate gyrus of adult rats are GABAergic basket cells (BCs). With the use of double whole-cell patch-clamp recordings from BC-GC pairs in hippocampal slices, we demonstrate that newly generated BCs in the dentate gyrus form inhibitory synapses with principal GCs. These data show for the first time that functional inhibitory neurons are recruited in the dentate gyrus of adult rats.

Key words: neurogenesis; functional inhibitory neurons; GABAergic interneurons; virus vectors; green fluorescent protein; adult rat dentate gyrus

---

Copyright © 2003 Society for Neuroscience  0270-6474/03/233732-05$05.00/0

This article has been cited by other articles:

				S.-W. Hou, Y.-Q. Wang, M. Xu, D.-H. Shen, J.-J. Wang, F. Huang, Z. Yu, and F.-Y. Sun Functional Integration of Newly Generated Neurons Into Striatum After Cerebral Ischemia in the Adult Rat Brain Stroke, October 1, 2008; 39(10): 2837 - 2844. [Abstract] [Full Text] [PDF]

				T. D. Perera, S. Park, and Y. Nemirovskaya Cognitive Role of Neurogenesis in Depression and Antidepressant Treatment Neuroscientist, August 1, 2008; 14(4): 326 - 338. [Abstract] [PDF]

				E. J. Kim, C. T. Leung, R. R. Reed, and J. E. Johnson In Vivo Analysis of Ascl1 Defined Progenitors Reveals Distinct Developmental Dynamics during Adult Neurogenesis and Gliogenesis J. Neurosci., November 21, 2007; 27(47): 12764 - 12774. [Abstract] [Full Text] [PDF]

				A. K. Shetty and B. Hattiangady Concise Review: Prospects of Stem Cell Therapy for Temporal Lobe Epilepsy Stem Cells, October 1, 2007; 25(10): 2396 - 2407. [Abstract] [Full Text] [PDF]

				T. D. Perera, J. D. Coplan, S. H. Lisanby, C. M. Lipira, M. Arif, C. Carpio, G. Spitzer, L. Santarelli, B. Scharf, R. Hen, et al. Antidepressant-Induced Neurogenesis in the Hippocampus of Adult Nonhuman Primates J. Neurosci., May 2, 2007; 27(18): 4894 - 4901. [Abstract] [Full Text] [PDF]

				V. C. Piatti, M. S. Esposito, and A. F. Schinder The Timing of Neuronal Development in Adult Hippocampal Neurogenesis Neuroscientist, December 1, 2006; 12(6): 463 - 468. [Abstract] [PDF]

				H.-S. Sun, Z.-P. Feng, T. Miki, S. Seino, and R. J. French Enhanced Neuronal Damage After Ischemic Insults in Mice Lacking Kir6.2-Containing ATP-Sensitive K+ Channels J Neurophysiol, April 1, 2006; 95(4): 2590 - 2601. [Abstract] [Full Text] [PDF]

				M. S. Esposito, V. C. Piatti, D. A. Laplagne, N. A. Morgenstern, C. C. Ferrari, F. J. Pitossi, and A. F. Schinder Neuronal Differentiation in the Adult Hippocampus Recapitulates Embryonic Development J. Neurosci., November 2, 2005; 25(44): 10074 - 10086. [Abstract] [Full Text] [PDF]

				Y. Wu, R. Kawakami, Y. Shinohara, M. Fukaya, K. Sakimura, M. Mishina, M. Watanabe, I. Ito, and R. Shigemoto Target-Cell-Specific Left-Right Asymmetry of NMDA Receptor Content in Schaffer Collateral Synapses in {epsilon}1/NR2A Knock-Out Mice J. Neurosci., October 5, 2005; 25(40): 9213 - 9226. [Abstract] [Full Text] [PDF]

				D. N. Abrous, M. Koehl, and M. Le Moal Adult Neurogenesis: From Precursors to Network and Physiology Physiol Rev, April 1, 2005; 85(2): 523 - 569. [Abstract] [Full Text] [PDF]

				A. F. Schinder and F. H. Gage A Hypothesis About the Role of Adult Neurogenesis in Hippocampal Function Physiology, October 1, 2004; 19(5): 253 - 261. [Abstract] [Full Text] [PDF]

				D. Y. Zhu, L. Lau, S. H. Liu, J. S. Wei, and Y. M. Lu Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus PNAS, June 22, 2004; 101(25): 9453 - 9457. [Abstract] [Full Text] [PDF]

				A. A. Aguirre, R. Chittajallu, S. Belachew, and V. Gallo NG2-expressing cells in the subventricular zone are type C-like cells and contribute to interneuron generation in the postnatal hippocampus J. Cell Biol., May 24, 2004; 165(4): 575 - 589. [Abstract] [Full Text] [PDF]

				L. S. Overstreet, S. T. Hentges, V. F. Bumaschny, F. S. J. de Souza, J. L. Smart, A. M. Santangelo, M. J. Low, G. L. Westbrook, and M. Rubinstein A Transgenic Marker for Newly Born Granule Cells in Dentate Gyrus J. Neurosci., March 31, 2004; 24(13): 3251 - 3259. [Abstract] [Full Text] [PDF]

				S. Belachew, R. Chittajallu, A. A. Aguirre, X. Yuan, M. Kirby, S. Anderson, and V. Gallo Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons J. Cell Biol., April 14, 2003; 161(1): 169 - 186. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help