QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (21) Citing Articles via Google Scholar Google Scholar Articles by Dhaka, A. Articles by Colicelli, J. Search for Related Content PubMed PubMed Citation Articles by Dhaka, A. Articles by Colicelli, J.

 Previous Article  |  Next Article 

The Journal of Neuroscience, February 1, 2003, 23(3):748

The RAS Effector RIN1 Modulates the Formation of Aversive Memories

Ajay Dhaka, Rui M. Costa², Hailiang Hu¹, Dwain K. Irvin³, Apoor Patel¹, Harley I. Kornblum³, Alcino J. Silva², Thomas J. O'Dell⁴, and John Colicelli¹

Departments of ¹ Biological Chemistry, ² Neurobiology, ³ Molecular and Medical Pharmacology, and ⁴ Physiology, and Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095-1737

RAS proteins are critical regulators of mitosis and are mutationally activated in many human tumors. RAS signaling is also known to mediate long-term potentiation (LTP) and long-term memory formation in postmitotic neurons, in part through activation of the RAF-MEK-ERK pathway. The RAS effector RIN1 appears to function through competitive inhibition of RAS-RAF binding and also through diversion of RAS signaling to alternate pathways. We show that RIN1 is preferentially expressed in postnatal forebrain neurons in which it is localized in dendrites and physically associated with RAS, suggesting a role in RAS-mediated postsynaptic neuronal plasticity. Mice with an Rin1 gene disruption showed a striking enhancement in amygdala LTP. In addition, two independent behavioral tests demonstrated elevated amygdala-dependent aversive memory in Rin1^/ mice. These results indicate that RIN1 serves as an inhibitory modulator of neuronal plasticity in aversive memory formation.

Key words: RIN1; RAS; ABL; amygdala; aversive memory; hippocampus; LTP; dendrites

---

Copyright © 2003 Society for Neuroscience  0270-6474/03/233748-10$05.00/0

This article has been cited by other articles:

				K. Deininger, M. Eder, E. R. Kramer, W. Zieglgansberger, H.-U. Dodt, K. Dornmair, J. Colicelli, and R. Klein The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons PNAS, August 26, 2008; 105(34): 12539 - 12544. [Abstract] [Full Text] [PDF]

				H. Hu, M. Milstein, J. M. Bliss, M. Thai, G. Malhotra, L. C. Huynh, and J. Colicelli Integration of Transforming Growth Factor {beta} and RAS Signaling Silences a RAB5 Guanine Nucleotide Exchange Factor and Enhances Growth Factor-Directed Cell Migration Mol. Cell. Biol., March 1, 2008; 28(5): 1573 - 1583. [Abstract] [Full Text] [PDF]

				S. Maren Building and Burying Fear Memories in the Brain Neuroscientist, February 1, 2005; 11(1): 89 - 99. [Abstract] [PDF]

				J. Colicelli Human RAS Superfamily Proteins and Related GTPases Sci. Signal., September 14, 2004; 2004(250): re13 - re13. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help