QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, October 29, 2003, 23(30):9752-9760

This Article Full Text Full Text (PDF) Supplemental Figure Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (31) Citing Articles via Google Scholar Google Scholar Articles by Peters, M. Articles by Giese, K. P. Search for Related Content PubMed PubMed Citation Articles by Peters, M. Articles by Giese, K. P.

 Previous Article  |  Next Article 

Cellular/Molecular
Loss of Ca²⁺/Calmodulin Kinase Kinase Affects the Formation of Some, But Not All, Types of Hippocampus-Dependent Long-Term Memory

Marco Peters,¹ Keiko Mizuno,¹ Laurence Ris,^1,2 Marco Angelo,¹ Emile Godaux,² and K. Peter Giese¹

¹Wolfson Institute for Biomedical Research, University College London, London, WC1E 6BT, United Kingdom, and ²Department of Neurosciences, University of Mons-Hainaut, 7000 Mons, Belgium

Long-term memory (LTM) requires activation of the transcription factor cAMP-responsive element binding protein (CREB). Signaling by the Ca²⁺/calmodulin (CaM) kinase cascade has been implicated in CREB activation and memory consolidation processes in the hippocampus. The CaM kinase kinase isoforms belong to the CaM kinase cascade, and we have generated null mutant mice to investigate the role of these kinases in several forms of learning and memory. The null mutants were impaired in spatial training-induced CREB activation and spatial memory formation. Furthermore, the mutants lacked late, but not early, long-term potentiation at the hippocampal CA1 synapse, and they were impaired in LTM, but not short-term memory, for the social transmission of food preferences. We suggest that the CaM kinase kinase isoforms are required for the formation of hippocampal LTM. Surprisingly, however, these kinases were not needed for contextual, trace fear, and passive avoidance LTM. Our results demonstrate that different signaling processes underlie the formation of these types of hippocampal LTM.

Key words: CREB; gene targeting; hippocampus; learning and memory; long-term potentiation; signaling

---

Received June 23, 2003; revised September 5, 2003; accepted September 6, 2003.

This article has been cited by other articles:

				F. Papaleo, J. N. Crawley, J. Song, B. K. Lipska, J. Pickel, D. R. Weinberger, and J. Chen Genetic Dissection of the Role of Catechol-O-Methyltransferase in Cognition and Stress Reactivity in Mice J. Neurosci., August 27, 2008; 28(35): 8709 - 8723. [Abstract] [Full Text] [PDF]

				A. Y. Hung, K. Futai, C. Sala, J. G. Valtschanoff, J. Ryu, M. A. Woodworth, F. L. Kidd, C. C. Sung, T. Miyakawa, M. F. Bear, et al. Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1 J. Neurosci., February 13, 2008; 28(7): 1697 - 1708. [Abstract] [Full Text] [PDF]

				A. Antunes-Martins, K. Mizuno, E. E. Irvine, E. M. Lepicard, and K. P. Giese Sex-dependent up-regulation of two splicing factors, Psf and Srp20, during hippocampal memory formation Learn. Mem., October 1, 2007; 14(10): 693 - 702. [Abstract] [Full Text] [PDF]

				K. Mizuno, L. Ris, A. Sanchez-Capelo, E. Godaux, and K. P. Giese Ca2+/Calmodulin Kinase Kinase {alpha} Is Dispensable for Brain Development but Is Required for Distinct Memories in Male, though Not in Female, Mice Mol. Cell. Biol., December 1, 2006; 26(23): 9094 - 9104. [Abstract] [Full Text] [PDF]

				F. Blaeser, M. J. Sanders, N. Truong, S. Ko, L. J. Wu, D. F. Wozniak, M. S. Fanselow, M. Zhuo, and T. A. Chatila Long-Term Memory Deficits in Pavlovian Fear Conditioning in Ca2+/Calmodulin Kinase Kinase {alpha}-Deficient Mice Mol. Cell. Biol., December 1, 2006; 26(23): 9105 - 9115. [Abstract] [Full Text] [PDF]

				J. M. Schmitt, E. S. Guire, T. Saneyoshi, and T. R. Soderling Calmodulin-Dependent Kinase Kinase/Calmodulin Kinase I Activity Gates Extracellular-Regulated Kinase-Dependent Long-Term Potentiation J. Neurosci., February 2, 2005; 25(5): 1281 - 1290. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help