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The Journal of Neuroscience, November 5, 2003, 23(31):10058-10063

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BRIEF COMMUNICATION
Globus Pallidus Discharge Is Coincident with Striatal Activity during Global Slow Wave Activity in the Rat

Joshua A. Goldberg,¹ Svetlana S. Kats,² and Dieter Jaeger²

¹Department of Physiology, The Hebrew University-Hadassah Medical School, and the Interdisciplinary Center for Neural Computation, The Hebrew University, Jerusalem, 91120, Israel, and ²Department of Biology, Emory University, Atlanta, Georgia 30322

The emergence of bursting and oscillations in the basal ganglia under normal and pathological conditions has attracted considerable interest, but the neural substrate of these patterns is poorly understood. Here we use multisite recordings in anesthetized rats to examine the relationship of globus pallidus (GP) spiking and striatal activity in relation to cortical slow-wave activity. We found that GP neurons displayed increased spike rates or bursts coincident with cortical activation and striatal up states. Furthermore, the onset of GP bursts typically coincides with transitions to striatal up states that precede striatal spiking. These data indicate that GP activity is driven by excitatory corticosubthalamic input during periods of synchronized bursting activity.

Key words: basal ganglia; synchrony; bursting; subthalamic nucleus; Parkinson's disease; inhibition

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Received May 26, 2003; revised September 20, 2003; accepted September 22, 2003.

This article has been cited by other articles:

				S. Li, G. W. Arbuthnott, M. J. Jutras, J. A. Goldberg, and D. Jaeger Resonant Antidromic Cortical Circuit Activation as a Consequence of High-Frequency Subthalamic Deep-Brain Stimulation J Neurophysiol, December 1, 2007; 98(6): 3525 - 3537. [Abstract] [Full Text] [PDF]

				S. Elias, M. Joshua, J. A. Goldberg, G. Heimer, D. Arkadir, G. Morris, and H. Bergman Statistical Properties of Pauses of the High-Frequency Discharge Neurons in the External Segment of the Globus Pallidus J. Neurosci., March 7, 2007; 27(10): 2525 - 2538. [Abstract] [Full Text] [PDF]

				F. Kasanetz, L. A. Riquelme, P. O'Donnell, and M. G. Murer Turning off cortical ensembles stops striatal Up states and elicits phase perturbations in cortical and striatal slow oscillations in rat in vivo J. Physiol., November 15, 2006; 577(1): 97 - 113. [Abstract] [Full Text] [PDF]

				N. C. Rowland and D. Jaeger Coding of Tactile Response Properties in the Rat Deep Cerebellar Nuclei J Neurophysiol, August 1, 2005; 94(2): 1236 - 1251. [Abstract] [Full Text] [PDF]

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