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The Journal of Neuroscience, November 12, 2003, 23(32):10224-10230
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Behavioral/Systems/Cognitive
Responses of Human Motoneurons to Corticospinal Stimulation during Maximal Voluntary Contractions and Ischemia
Jane E. Butler, Janet L. Taylor, andSimon C. Gandevia Prince of Wales Medical Research Institute and University of New South Wales, Randwick, New South Wales, 2031 Australia
The discharge frequency of human motoneurons declines during a sustained isometric maximal voluntary contraction (MVC) of elbow flexor muscles, but the cause is unresolved. We aimed to determine whether motoneurons were inhibited during a sustained fatiguing contraction of the elbow flexor muscles and whether this inhibition was caused by the discharge of group III and IV muscle afferents. Subjects performed brief MVCs before and after a fatiguing 2 min MVC. During maximal efforts, electromyographic responses recorded from the elbow flexor muscles were evoked by stimulation of the corticospinal tracts at the cervicomedullary level [cervicomedullary motor evoked potentials (CMEPs)] and by supramaximal stimulation over the brachial plexus (Mmax). This revealed a novel decrease in the size of the muscle response to corticospinal tract stimulation during fatigue. During the sustained MVCs, the size of CMEPs decreased to 81 ± 15 and 78 ± 15% of the control value for brachioradialis and biceps brachii, respectively (mean ± SEM; n = 8). This recovered within 15 sec after the fatiguing contraction. In a second set of studies, input from group III and IV muscle afferents was prolonged after the end of the fatiguing contraction by holding the muscle ischemic with a cuff inflated above arterial pressure. Despite the maintained discharge of group III and IV afferents, the CMEPs again recovered within 15 sec of the end of the sustained contraction. These results show a diminished output of spinal motoneurons to stimulation of corticospinal tracts during a fatiguing MVC; however, the mechanisms responsible for this decline are not attributable to activity in group III and IV muscle afferents.
Key words: fatigue; motoneuron (motor neuron); group III and IV muscle afferents; human; corticospinal; ischemia
Received July 8, 2003; revised September 14, 2003; accepted September 16, 2003.
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